Pleiotropic vascular protective effects of statins in perioperative medicine

Shi-Yuan Fang, Jun-Neng Roan, Chwan-Yau Luo, Yu-Chuan Tsai, Chen Fuh Lam

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (statins) is one of the most commonly prescribed agents for controlling hyperlipidemia. Apart from their lipid-lowering property, statins are well known for their pleiotropic effects, such as improvement of vascular endothelial dysfunction, attenuation of inflammatory responses, stabilization of atherosclerotic plaques, inhibition of vascular smooth muscle proliferation, and modulation of procoagulant activity and platelet function. The vasculoprotective effect of statins is mainly mediated by inhibition of the mevalonate pathway and oxidized low-density lipoprotein generation, thereby enhancing the biosynthesis of endothelium-derived nitric oxide. Accumulating clinical evidence strongly suggests that administration of statins reduces overall mortality, the development myocardial infarction and atrial fibrillation, and length of hospital stay after a major cardiac/noncardiac surgery. This review updates the clinical pharmacology and therapeutic applications of statins during major operations, and highlights the anesthesia considerations for perioperative statin therapy.

Original languageEnglish
Pages (from-to)120-126
Number of pages7
JournalActa Anaesthesiologica Taiwanica
Volume51
Issue number3
DOIs
Publication statusPublished - 2013 Sep 1

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Blood Vessels
Medicine
Length of Stay
Mevalonic Acid
Clinical Pharmacology
Atherosclerotic Plaques
Hyperlipidemias
Vascular Smooth Muscle
Atrial Fibrillation
Thoracic Surgery
Oxidoreductases
Nitric Oxide
Blood Platelets
Anesthesia
Myocardial Infarction
Lipids
Mortality
Therapeutics

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

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title = "Pleiotropic vascular protective effects of statins in perioperative medicine",
abstract = "3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (statins) is one of the most commonly prescribed agents for controlling hyperlipidemia. Apart from their lipid-lowering property, statins are well known for their pleiotropic effects, such as improvement of vascular endothelial dysfunction, attenuation of inflammatory responses, stabilization of atherosclerotic plaques, inhibition of vascular smooth muscle proliferation, and modulation of procoagulant activity and platelet function. The vasculoprotective effect of statins is mainly mediated by inhibition of the mevalonate pathway and oxidized low-density lipoprotein generation, thereby enhancing the biosynthesis of endothelium-derived nitric oxide. Accumulating clinical evidence strongly suggests that administration of statins reduces overall mortality, the development myocardial infarction and atrial fibrillation, and length of hospital stay after a major cardiac/noncardiac surgery. This review updates the clinical pharmacology and therapeutic applications of statins during major operations, and highlights the anesthesia considerations for perioperative statin therapy.",
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Pleiotropic vascular protective effects of statins in perioperative medicine. / Fang, Shi-Yuan; Roan, Jun-Neng; Luo, Chwan-Yau; Tsai, Yu-Chuan; Lam, Chen Fuh.

In: Acta Anaesthesiologica Taiwanica, Vol. 51, No. 3, 01.09.2013, p. 120-126.

Research output: Contribution to journalReview article

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AU - Fang, Shi-Yuan

AU - Roan, Jun-Neng

AU - Luo, Chwan-Yau

AU - Tsai, Yu-Chuan

AU - Lam, Chen Fuh

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AB - 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (statins) is one of the most commonly prescribed agents for controlling hyperlipidemia. Apart from their lipid-lowering property, statins are well known for their pleiotropic effects, such as improvement of vascular endothelial dysfunction, attenuation of inflammatory responses, stabilization of atherosclerotic plaques, inhibition of vascular smooth muscle proliferation, and modulation of procoagulant activity and platelet function. The vasculoprotective effect of statins is mainly mediated by inhibition of the mevalonate pathway and oxidized low-density lipoprotein generation, thereby enhancing the biosynthesis of endothelium-derived nitric oxide. Accumulating clinical evidence strongly suggests that administration of statins reduces overall mortality, the development myocardial infarction and atrial fibrillation, and length of hospital stay after a major cardiac/noncardiac surgery. This review updates the clinical pharmacology and therapeutic applications of statins during major operations, and highlights the anesthesia considerations for perioperative statin therapy.

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