PML: Regulation and multifaceted function beyond tumor suppression

Kuo Sheng Hsu, Hung Ying Kao

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic acid receptor alpha in acute promyelocytic leukemia patients with the (15;17) chromosomal translocation, giving rise to PML-RARα and RARα-PML fusion proteins. A body of evidence indicated that PML possesses tumor suppressing activity by regulating apoptosis, cell cycle, senescence and DNA damage responses. PML is enriched in discrete nuclear substructures in mammalian cells with 0.2-1 μm diameter in size, referred to as alternately Kremer bodies, nuclear domain 10, PML oncogenic domains or PML nuclear bodies (NBs). Dysregulation of PML NB formation results in altered transcriptional regulation, protein modification, apoptosis and cellular senescence. In addition to PML NBs, PML is also present in nucleoplasm and cytoplasmic compartments, including the endoplasmic reticulum and mitochondria-associated membranes. The role of PML in tumor suppression has been extensively studied but increasing evidence indicates that PML also plays versatile roles in stem cell renewal, metabolism, inflammatory responses, neural function, mammary development and angiogenesis. In this review, we will briefly describe the known PML regulation and function and include new findings.

Original languageEnglish
Article number5
JournalCell and Bioscience
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Jan 25

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Tumors
Neoplasms
Proteins
Nuclear Proteins
Cell Aging
Promyelocytic Leukemia Protein
Fusion reactions
Cells
Apoptosis
Retinoic Acid Receptors
Mitochondria
Genetic Translocation
Acute Promyelocytic Leukemia
Stem cells
Metabolism
Endoplasmic Reticulum
DNA Damage
Cell Cycle
Breast
Membranes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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PML : Regulation and multifaceted function beyond tumor suppression. / Hsu, Kuo Sheng; Kao, Hung Ying.

In: Cell and Bioscience, Vol. 8, No. 1, 5, 25.01.2018.

Research output: Contribution to journalReview article

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