Pneumococcal pneumonia and influenza: A deadly combination

Keith P. Klugman; Yu Wen Chien; Shabir A. Madhi

doi:10.1016/j.vaccine.2009.06.007

Pneumococcal pneumonia and influenza: A deadly combination

Keith P. Klugman, Yu Wen Chien, Shabir A. Madhi

Department of Public Health

Research output: Contribution to journal › Article › peer-review

117 Citations (Scopus)

Abstract

Significant morbidity due to pneumococcal co-infection is associated with viral respiratory infections. Pneumonia is the leading cause of death in children worldwide. The incidence of clinical pneumonia among children in the United States decreased 39% following the introduction of a seven-valent pneumococcal conjugate vaccine (PCV). PCVs have also reduced hospitalisations associated with influenza in children. The majority of the mortality associated with the influenza pandemic of 1918 was attributable to bacterial infections, especially the pneumococcus. Vaccination with PCV for children and pneumococcal polysaccharide vaccine for adults should be considered essential to pandemic influenza preparedness.

Original language	English
Pages (from-to)	C9-C14
Journal	Vaccine
Volume	27
Issue number	SUPPL. 3
DOIs	https://doi.org/10.1016/j.vaccine.2009.06.007
Publication status	Published - 2009 Aug 21

All Science Journal Classification (ASJC) codes

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2009.06.007

Cite this

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title = "Pneumococcal pneumonia and influenza: A deadly combination",

abstract = "Significant morbidity due to pneumococcal co-infection is associated with viral respiratory infections. Pneumonia is the leading cause of death in children worldwide. The incidence of clinical pneumonia among children in the United States decreased 39% following the introduction of a seven-valent pneumococcal conjugate vaccine (PCV). PCVs have also reduced hospitalisations associated with influenza in children. The majority of the mortality associated with the influenza pandemic of 1918 was attributable to bacterial infections, especially the pneumococcus. Vaccination with PCV for children and pneumococcal polysaccharide vaccine for adults should be considered essential to pandemic influenza preparedness.",

author = "Klugman, {Keith P.} and Chien, {Yu Wen} and Madhi, {Shabir A.}",

note = "Funding Information: The authors thank Excerpta Medica (Bridgewater, NJ) for professional writing assistance, which was funded by Wyeth Pharmaceuticals, Collegeville, PA. Conflicts of interest : Dr Klugman has received research support and consultant fees from Wyeth and consultant fees from Merck. Dr Chien declares that he has no conflict of interest related to the content of this manuscript. Dr Madhi has received speaker's honorarium and research support from Wyeth and GlaxoSmithKline. ",

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AU - Madhi, Shabir A.

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AB - Significant morbidity due to pneumococcal co-infection is associated with viral respiratory infections. Pneumonia is the leading cause of death in children worldwide. The incidence of clinical pneumonia among children in the United States decreased 39% following the introduction of a seven-valent pneumococcal conjugate vaccine (PCV). PCVs have also reduced hospitalisations associated with influenza in children. The majority of the mortality associated with the influenza pandemic of 1918 was attributable to bacterial infections, especially the pneumococcus. Vaccination with PCV for children and pneumococcal polysaccharide vaccine for adults should be considered essential to pandemic influenza preparedness.

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Pneumococcal pneumonia and influenza: A deadly combination

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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