Pneumomediastinum in patients with AIDS: A case report and literature review

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Objective: Pneumomediastinum is a rare complication of opportunistic infections in HIV-infected patients. However, the relationship between the causative pathogens and the prognosis is unclear. We report the case of a patient with AIDS presenting with community-acquired pneumonia complicated by pneumomediastinum. The cases of a further 10 HIV-infected patients with pneumomediastinum reported in the English language literature are reviewed. Methods: PubMed was searched for cases of HIV-infected patients with pneumomediastinum published in the English language literature. Results: Pneumocystis jirovecii is the most common pathogen causing pneumonia and concurrent pneumomediastinum in HIV-infected patients. Only one of the identified cases was caused by cytomegalovirus. Excluding the two cases with incomplete information, the overall mortality rate in the remaining nine cases was 55.5%. Conclusion: In HIV-infected patients, Pneumocystis jirovecii pneumonia can occasionally present as pneumomediastinum. In such cases, adequate appropriate antimicrobial therapy is needed due to the high mortality rate.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalInternational Journal of Infectious Diseases
Volume22
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Mediastinal Emphysema
Acquired Immunodeficiency Syndrome
HIV
Pneumocystis carinii
Pneumonia
Language
Pneumocystis Pneumonia
Mortality
Opportunistic Infections
Cytomegalovirus
PubMed

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{116849fdfc9f4ce082ec571400773cfa,
title = "Pneumomediastinum in patients with AIDS: A case report and literature review",
abstract = "Objective: Pneumomediastinum is a rare complication of opportunistic infections in HIV-infected patients. However, the relationship between the causative pathogens and the prognosis is unclear. We report the case of a patient with AIDS presenting with community-acquired pneumonia complicated by pneumomediastinum. The cases of a further 10 HIV-infected patients with pneumomediastinum reported in the English language literature are reviewed. Methods: PubMed was searched for cases of HIV-infected patients with pneumomediastinum published in the English language literature. Results: Pneumocystis jirovecii is the most common pathogen causing pneumonia and concurrent pneumomediastinum in HIV-infected patients. Only one of the identified cases was caused by cytomegalovirus. Excluding the two cases with incomplete information, the overall mortality rate in the remaining nine cases was 55.5{\%}. Conclusion: In HIV-infected patients, Pneumocystis jirovecii pneumonia can occasionally present as pneumomediastinum. In such cases, adequate appropriate antimicrobial therapy is needed due to the high mortality rate.",
author = "Cheng, {Wan Ling} and Wen-Chien Ko and Nan-Yao Lee and Chia-Ming Chang and Lee, {Ching Chi} and Ming-Chi Li and Chia-Wen Li",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.ijid.2013.12.009",
language = "English",
volume = "22",
pages = "31--34",
journal = "International Journal of Infectious Diseases",
issn = "1201-9712",
publisher = "Elsevier",

}

TY - JOUR

T1 - Pneumomediastinum in patients with AIDS

T2 - A case report and literature review

AU - Cheng, Wan Ling

AU - Ko, Wen-Chien

AU - Lee, Nan-Yao

AU - Chang, Chia-Ming

AU - Lee, Ching Chi

AU - Li, Ming-Chi

AU - Li, Chia-Wen

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective: Pneumomediastinum is a rare complication of opportunistic infections in HIV-infected patients. However, the relationship between the causative pathogens and the prognosis is unclear. We report the case of a patient with AIDS presenting with community-acquired pneumonia complicated by pneumomediastinum. The cases of a further 10 HIV-infected patients with pneumomediastinum reported in the English language literature are reviewed. Methods: PubMed was searched for cases of HIV-infected patients with pneumomediastinum published in the English language literature. Results: Pneumocystis jirovecii is the most common pathogen causing pneumonia and concurrent pneumomediastinum in HIV-infected patients. Only one of the identified cases was caused by cytomegalovirus. Excluding the two cases with incomplete information, the overall mortality rate in the remaining nine cases was 55.5%. Conclusion: In HIV-infected patients, Pneumocystis jirovecii pneumonia can occasionally present as pneumomediastinum. In such cases, adequate appropriate antimicrobial therapy is needed due to the high mortality rate.

AB - Objective: Pneumomediastinum is a rare complication of opportunistic infections in HIV-infected patients. However, the relationship between the causative pathogens and the prognosis is unclear. We report the case of a patient with AIDS presenting with community-acquired pneumonia complicated by pneumomediastinum. The cases of a further 10 HIV-infected patients with pneumomediastinum reported in the English language literature are reviewed. Methods: PubMed was searched for cases of HIV-infected patients with pneumomediastinum published in the English language literature. Results: Pneumocystis jirovecii is the most common pathogen causing pneumonia and concurrent pneumomediastinum in HIV-infected patients. Only one of the identified cases was caused by cytomegalovirus. Excluding the two cases with incomplete information, the overall mortality rate in the remaining nine cases was 55.5%. Conclusion: In HIV-infected patients, Pneumocystis jirovecii pneumonia can occasionally present as pneumomediastinum. In such cases, adequate appropriate antimicrobial therapy is needed due to the high mortality rate.

UR - http://www.scopus.com/inward/record.url?scp=84897094008&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897094008&partnerID=8YFLogxK

U2 - 10.1016/j.ijid.2013.12.009

DO - 10.1016/j.ijid.2013.12.009

M3 - Review article

C2 - 24589680

AN - SCOPUS:84897094008

VL - 22

SP - 31

EP - 34

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

SN - 1201-9712

ER -