Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region

Hayato Tada, Khung Keong Yeo, Jian Jun Li, Kathryn Tan, Junya Ako, Rungroj Krittayaphong, Ru San Tan, Philip E. Aylward, Carolyn S.P. Lam, Sang Hong Baek, Jamshed Dalal, Alan Fong, Yi Heng Li, Richard C. O'Brien, Si Ya Natalie Koh, Daniel J. Scherer, Vernon Kang, Adam J. Nelson, Julie Butters, Stephen J. Nicholls

Research output: Contribution to journalReview articlepeer-review

Abstract

Approximately one-half of the phenotypic susceptibility to atherosclerotic cardiovascular disease (ASCVD) has a genetic basis. Although individual allelic variants generally impart a small effect on risk for ASCVD, an emerging body of data has shown that the aggregation and weighting of many of these genetic variations into “scores” can further discriminate an individual's risk beyond traditional risk factors alone. Consistent with the theory of population genetics, such polygenic risk scores (PRS) appear to be ethnicity specific because their elements comprise single-nucleotide variants that are always ethnicity specific. The currently available PRS are derived predominantly from European ancestry and thus predictably perform less well among non-European participants, a fact that has implications for their use in the Asia-Pacific region. This paper describes the current state of knowledge of PRS, the available data that support their use in this region, and highlights the needs moving forward to safely and effectively implement them in clinical care in the Asia-Pacific region.

Original languageEnglish
Pages (from-to)294-302
Number of pages9
JournalJACC: Asia
Volume1
Issue number3
DOIs
Publication statusPublished - 2021 Dec

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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