Polymer microneedles fabricated from PCL and PCL/PEG blends for transdermal delivery of hydrophilic compounds

Pei Ting Ko; I. Chi Lee; Mei Chin Chen; Shau Wei Tsai

doi:10.1016/j.jtice.2015.01.003

Polymer microneedles fabricated from PCL and PCL/PEG blends for transdermal delivery of hydrophilic compounds

Pei Ting Ko, I. Chi Lee, Mei Chin Chen, Shau Wei Tsai

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

The merits of low-cost, easy-fabrication, and FDA-approved biodegradable poly-ε-caprolactone (PCL) and dissolving poly(ethylene glycol) (PEG) have initiated our research on developing a gentle fabrication method consisting of solution-casting process in sequence with thermal press molding for preparing microneedle (MN) patches with model hydrophilic compounds of rhodamine 6G and fluorescein isothiocyanate (FITC)-labeled collagen encapsulated in the MN tip. The best PCL/PEG molar ratio of 1/19 was selected for molding the tip after considering the MN performances from mechanical compression and in vitro drug-release tests. A modified Korsmeyer and Peppas model was further proposed to simulate and elucidate the initial burst and slow dissociation-diffusion of the model drugs into the phosphate buffer. Moreover, the confocal microscope images at the insertion depth around 200 μm to the porcine skin together with drug permeation tests in a Franz-type diffusion cell showed that both drugs might rapidly dissolve and diffuse across the skin. These results suggest that the designed MN patches may serve as a useful device for transdermal delivery of hydrophilic biomolecules in a short-term manner.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Journal of the Taiwan Institute of Chemical Engineers
Volume	51
DOIs	https://doi.org/10.1016/j.jtice.2015.01.003
Publication status	Published - 2015 Jun 1

All Science Journal Classification (ASJC) codes

General Chemistry
General Chemical Engineering

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10.1016/j.jtice.2015.01.003

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title = "Polymer microneedles fabricated from PCL and PCL/PEG blends for transdermal delivery of hydrophilic compounds",

abstract = "The merits of low-cost, easy-fabrication, and FDA-approved biodegradable poly-ε-caprolactone (PCL) and dissolving poly(ethylene glycol) (PEG) have initiated our research on developing a gentle fabrication method consisting of solution-casting process in sequence with thermal press molding for preparing microneedle (MN) patches with model hydrophilic compounds of rhodamine 6G and fluorescein isothiocyanate (FITC)-labeled collagen encapsulated in the MN tip. The best PCL/PEG molar ratio of 1/19 was selected for molding the tip after considering the MN performances from mechanical compression and in vitro drug-release tests. A modified Korsmeyer and Peppas model was further proposed to simulate and elucidate the initial burst and slow dissociation-diffusion of the model drugs into the phosphate buffer. Moreover, the confocal microscope images at the insertion depth around 200 μm to the porcine skin together with drug permeation tests in a Franz-type diffusion cell showed that both drugs might rapidly dissolve and diffuse across the skin. These results suggest that the designed MN patches may serve as a useful device for transdermal delivery of hydrophilic biomolecules in a short-term manner.",

author = "Ko, {Pei Ting} and Lee, {I. Chi} and Chen, {Mei Chin} and Tsai, {Shau Wei}",

note = "Funding Information: The financial support of CMRPD1C0432 from Chang Gung Memorial Hospital and experimental assistances from Professors Mu-Yi Hua and Juh-Ping Chen (Department of Chemical and Materials Engineering, Chang Gung University) are appreciated. Publisher Copyright: {\textcopyright} 2015 Taiwan Institute of Chemical Engineers.",

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AU - Ko, Pei Ting

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N1 - Funding Information: The financial support of CMRPD1C0432 from Chang Gung Memorial Hospital and experimental assistances from Professors Mu-Yi Hua and Juh-Ping Chen (Department of Chemical and Materials Engineering, Chang Gung University) are appreciated. Publisher Copyright: © 2015 Taiwan Institute of Chemical Engineers.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - The merits of low-cost, easy-fabrication, and FDA-approved biodegradable poly-ε-caprolactone (PCL) and dissolving poly(ethylene glycol) (PEG) have initiated our research on developing a gentle fabrication method consisting of solution-casting process in sequence with thermal press molding for preparing microneedle (MN) patches with model hydrophilic compounds of rhodamine 6G and fluorescein isothiocyanate (FITC)-labeled collagen encapsulated in the MN tip. The best PCL/PEG molar ratio of 1/19 was selected for molding the tip after considering the MN performances from mechanical compression and in vitro drug-release tests. A modified Korsmeyer and Peppas model was further proposed to simulate and elucidate the initial burst and slow dissociation-diffusion of the model drugs into the phosphate buffer. Moreover, the confocal microscope images at the insertion depth around 200 μm to the porcine skin together with drug permeation tests in a Franz-type diffusion cell showed that both drugs might rapidly dissolve and diffuse across the skin. These results suggest that the designed MN patches may serve as a useful device for transdermal delivery of hydrophilic biomolecules in a short-term manner.

AB - The merits of low-cost, easy-fabrication, and FDA-approved biodegradable poly-ε-caprolactone (PCL) and dissolving poly(ethylene glycol) (PEG) have initiated our research on developing a gentle fabrication method consisting of solution-casting process in sequence with thermal press molding for preparing microneedle (MN) patches with model hydrophilic compounds of rhodamine 6G and fluorescein isothiocyanate (FITC)-labeled collagen encapsulated in the MN tip. The best PCL/PEG molar ratio of 1/19 was selected for molding the tip after considering the MN performances from mechanical compression and in vitro drug-release tests. A modified Korsmeyer and Peppas model was further proposed to simulate and elucidate the initial burst and slow dissociation-diffusion of the model drugs into the phosphate buffer. Moreover, the confocal microscope images at the insertion depth around 200 μm to the porcine skin together with drug permeation tests in a Franz-type diffusion cell showed that both drugs might rapidly dissolve and diffuse across the skin. These results suggest that the designed MN patches may serve as a useful device for transdermal delivery of hydrophilic biomolecules in a short-term manner.

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Polymer microneedles fabricated from PCL and PCL/PEG blends for transdermal delivery of hydrophilic compounds

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