Polymeric nanotherapeutics: Clinical development and advances in stealth functionalization strategies

Che-Ming Hu, Ronnie H. Fang, Brian T. Luk, Liangfang Zhang

Research output: Contribution to journalArticlepeer-review

122 Citations (Scopus)

Abstract

Long-circulating polymeric nanotherapeutics have garnered increasing interest in research and in the clinic owing to their ability to improve the solubility and pharmacokinetics of therapeutic cargoes. Modulation of carrier properties promises more effective drug localization at the disease sites and can lead to enhanced drug safety and efficacy. In the present review, we highlight the current development of polymeric nanotherapeutics in the clinic. In light of the importance of stealth properties in therapeutic nanoparticles, we also review the advances in stealth functionalization strategies and examine the performance of different stealth polymers in the literature. In addition, we discuss the recent development of biologically inspired "self" nanoparticles, which present a differing stealth concept from conventional approaches.

Original languageEnglish
Pages (from-to)65-75
Number of pages11
JournalNanoscale
Volume6
Issue number1
DOIs
Publication statusPublished - 2014 Jan 7

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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