Polymorphism in the hMSH2 gene (gISV12-6T > C) is a prognostic factor in non-small cell lung cancer

Han Shui Hsu, I. Hsuan Lee, Wen Hu Hsu, Wei Ting Kao, Yi-Ching Wang

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Abstract

Genetic polymorphisms at the genes involved in mismatch repair may determine individual's susceptibility to cancer initiation and progression. However, the prognostic significance of hMSH2 gIVS12-6T > C polymorphism (T-C substitution at the -6 intronic splice acceptor site of exon 13) in non-small cell lung cancer (NSCLC) remains unclear. Therefore, we investigated the frequency of hMSH2 gIVS12-6T > C polymorphism in 156 NSCLC patients and 235 cancer-free individuals matched for age, gender and smoking habit. The correlations between hMSH2 genotypes and protein expression and survival of the patients were also analyzed. The frequencies of hMSH2 genotypes T/T, T/C, and C/C were 37.4%, 43.0%, and 19.6%, respectively, and the variant (C) allele was represented at a significantly higher frequency in the general Taiwanese population than in non-Asian populations (P < 0.0001, χ2 test). No significant difference in hMSH2 genotype distribution was found between NSCLC patients and cancer-free controls (P = 0.255, multivariate logistic regression). However, the homozygous wild-type T/T genotype was significantly associated with a poor prognosis (P = 0.007, log-rank test). Our study showed that the frequency of the variant C allele was significantly higher in the general Taiwanese population than in non-Asian populations and the T/T genotype of hMSH2 gIVS12-6T > C polymorphism was a poor prognostic factor in NSCLC patients.

Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalLung Cancer
Volume58
Issue number1
DOIs
Publication statusPublished - 2007 Oct 1

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Non-Small Cell Lung Carcinoma
Genotype
Genes
RNA Splice Sites
DNA Mismatch Repair
Genetic Polymorphisms
Population
Habits
Exons
Neoplasms
Smoking
Alleles
Survival
Proteins

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Hsu, Han Shui ; Lee, I. Hsuan ; Hsu, Wen Hu ; Kao, Wei Ting ; Wang, Yi-Ching. / Polymorphism in the hMSH2 gene (gISV12-6T > C) is a prognostic factor in non-small cell lung cancer. In: Lung Cancer. 2007 ; Vol. 58, No. 1. pp. 123-130.
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title = "Polymorphism in the hMSH2 gene (gISV12-6T > C) is a prognostic factor in non-small cell lung cancer",
abstract = "Genetic polymorphisms at the genes involved in mismatch repair may determine individual's susceptibility to cancer initiation and progression. However, the prognostic significance of hMSH2 gIVS12-6T > C polymorphism (T-C substitution at the -6 intronic splice acceptor site of exon 13) in non-small cell lung cancer (NSCLC) remains unclear. Therefore, we investigated the frequency of hMSH2 gIVS12-6T > C polymorphism in 156 NSCLC patients and 235 cancer-free individuals matched for age, gender and smoking habit. The correlations between hMSH2 genotypes and protein expression and survival of the patients were also analyzed. The frequencies of hMSH2 genotypes T/T, T/C, and C/C were 37.4{\%}, 43.0{\%}, and 19.6{\%}, respectively, and the variant (C) allele was represented at a significantly higher frequency in the general Taiwanese population than in non-Asian populations (P < 0.0001, χ2 test). No significant difference in hMSH2 genotype distribution was found between NSCLC patients and cancer-free controls (P = 0.255, multivariate logistic regression). However, the homozygous wild-type T/T genotype was significantly associated with a poor prognosis (P = 0.007, log-rank test). Our study showed that the frequency of the variant C allele was significantly higher in the general Taiwanese population than in non-Asian populations and the T/T genotype of hMSH2 gIVS12-6T > C polymorphism was a poor prognostic factor in NSCLC patients.",
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Polymorphism in the hMSH2 gene (gISV12-6T > C) is a prognostic factor in non-small cell lung cancer. / Hsu, Han Shui; Lee, I. Hsuan; Hsu, Wen Hu; Kao, Wei Ting; Wang, Yi-Ching.

In: Lung Cancer, Vol. 58, No. 1, 01.10.2007, p. 123-130.

Research output: Contribution to journalArticle

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AU - Hsu, Han Shui

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AB - Genetic polymorphisms at the genes involved in mismatch repair may determine individual's susceptibility to cancer initiation and progression. However, the prognostic significance of hMSH2 gIVS12-6T > C polymorphism (T-C substitution at the -6 intronic splice acceptor site of exon 13) in non-small cell lung cancer (NSCLC) remains unclear. Therefore, we investigated the frequency of hMSH2 gIVS12-6T > C polymorphism in 156 NSCLC patients and 235 cancer-free individuals matched for age, gender and smoking habit. The correlations between hMSH2 genotypes and protein expression and survival of the patients were also analyzed. The frequencies of hMSH2 genotypes T/T, T/C, and C/C were 37.4%, 43.0%, and 19.6%, respectively, and the variant (C) allele was represented at a significantly higher frequency in the general Taiwanese population than in non-Asian populations (P < 0.0001, χ2 test). No significant difference in hMSH2 genotype distribution was found between NSCLC patients and cancer-free controls (P = 0.255, multivariate logistic regression). However, the homozygous wild-type T/T genotype was significantly associated with a poor prognosis (P = 0.007, log-rank test). Our study showed that the frequency of the variant C allele was significantly higher in the general Taiwanese population than in non-Asian populations and the T/T genotype of hMSH2 gIVS12-6T > C polymorphism was a poor prognostic factor in NSCLC patients.

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