Polymorphisms of EHF-ELF5 genomic region and its association with pediatric asthma in the Taiwanese population

Jiu Yao Wang, Shyh Dar Shyur, Frada Wei Sam Lam, Lawrence Shih Hsin Wu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background The EHF and ELF5 genes, located on chromosome 11p and linked to asthma phenotypes, are high-potential candidate genes conferring asthma susceptibility. The purpose of this study was to investigate the genetic association among single nucleotide polymorphisms (SNPs) of EHF and ELF5, and their relationship with asthma in the Taiwanese population. Methods We selected and performed genotyping on 16 SNPs that encompass the genomic region of EHF and ELF5 in Taiwanese children with or without asthma. A total of 1983 children, 523 in the test group and 619 and 842 in two validation groups, were recruited for this study. Results The SNP rs3910901, located in the 5′ upstream region of ELF5, was found to have a weak association (p = 0.043) with asthma in the odds ratio analysis. The genotype distribution was similar in all comparison groups, but the CC genotype was more frequent in asthma patients. Logistic regression adjusted allergy comorbidity showed obviously diluted association. Conclusion The results indicated that SNP rs3910901 may have a minor impact on pediatric asthma in the Taiwanese population.

Original languageEnglish
Pages (from-to)879-884
Number of pages6
JournalJournal of Microbiology, Immunology and Infection
Volume49
Issue number6
DOIs
Publication statusPublished - 2016 Dec 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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