TY - JOUR
T1 - Polymorphisms within the Tumor Necrosis Factor-Alpha Gene Is Associated with Preeclampsia in Taiwanese Han Populations
AU - Lin, Chih Wei
AU - Chen, Chung Hwan
AU - Wu, Meng Hsing
AU - Chang, Fong Ming
AU - Kang, Lin
N1 - Funding Information:
This study was supported in part by the National Health Research Institute (NHRI-EX112-11224EI) of Taiwan, National Cheng Kung University (NCKUH-10406014), Kaohsiung Municipal Ta-Tung Hospital (KMTTH-111-R002 and KMTTH-DK(A)112001), Kaohsiung Medical University (NPUST KMU-111-P005, KMU-TC111A02-1, KMU-DK(A)110003 and KMU-DK(B) 110002) and the Minister of Science and Technology, Taiwan (MOST 106-2314-B-006-066, 108-2314-B-006-062, 110-2314-B-006-037-MY3, 110-2314-B-037-029-MY3, MOST111-2314-B-037-106) of Taiwan. The funders had no role in the study design, data collection, and analysis; decision to publish; or preparation of the manuscript.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/3
Y1 - 2023/3
N2 - Preeclampsia (PE) occurs in women pregnant for more than 20 weeks with de novo hypertension and proteinuria, and is a devastating disease in maternal–fetal medicine. Cytokine tumor necrosis factor (TNF)-α may play a key role in the pathogenesis of PE. We conducted this study to investigate the regulatory regions of the TNF genes, by investigating two promoter polymorphisms, TNFA-308G/A (rs1800629) and -238G/A (rs361525), known to influence TNF expression, and their relationship to PE. An observational, monocentric, case–control study was conducted. We retrospectively collected 74 cases of severe PE and 119 pregnant women without PE as control. Polymerase chain reaction (PCR) was carried out for allele analysis. Higher A allele in women with PE was found in rs1800629 but not rs361525. In this study, we first found that polymorphism at the position -308, but not -238, in the promoter region of the TNF-α gene can contribute to severe PE in Taiwanese Han populations. The results of our study are totally different to previous Iranian studies, but have some similarity to a previous UK study. Further studies are required to confirm the roles of rs1800629 and rs361525 in PE with circulating TNF-α in PE.
AB - Preeclampsia (PE) occurs in women pregnant for more than 20 weeks with de novo hypertension and proteinuria, and is a devastating disease in maternal–fetal medicine. Cytokine tumor necrosis factor (TNF)-α may play a key role in the pathogenesis of PE. We conducted this study to investigate the regulatory regions of the TNF genes, by investigating two promoter polymorphisms, TNFA-308G/A (rs1800629) and -238G/A (rs361525), known to influence TNF expression, and their relationship to PE. An observational, monocentric, case–control study was conducted. We retrospectively collected 74 cases of severe PE and 119 pregnant women without PE as control. Polymerase chain reaction (PCR) was carried out for allele analysis. Higher A allele in women with PE was found in rs1800629 but not rs361525. In this study, we first found that polymorphism at the position -308, but not -238, in the promoter region of the TNF-α gene can contribute to severe PE in Taiwanese Han populations. The results of our study are totally different to previous Iranian studies, but have some similarity to a previous UK study. Further studies are required to confirm the roles of rs1800629 and rs361525 in PE with circulating TNF-α in PE.
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U2 - 10.3390/biomedicines11030862
DO - 10.3390/biomedicines11030862
M3 - Article
AN - SCOPUS:85151563773
SN - 2227-9059
VL - 11
JO - Biomedicines
JF - Biomedicines
IS - 3
M1 - 862
ER -