Polysaccharides obtained from mycelia of cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy

Ruo Kai Lin, Chen Yen Choong, Wei-Hsuan Hsu, Chen Jei Tai, Cheng Jeng Tai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: Fungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy. Methods: Doxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells. Results: PS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells. Conclusion: These findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.

Original languageEnglish
Pages (from-to)2156-2163
Number of pages8
JournalAfrican Health Sciences
Volume19
Issue number2
DOIs
Publication statusPublished - 2019 Jun 1

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Cordyceps
Mycelium
Doxorubicin
Polysaccharides
Drug Therapy
Cytokines
Functional Food
Chinese Traditional Medicine
Monocytes
Cell Survival
Fungi
Cell Death
Cell Proliferation
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lin, Ruo Kai ; Choong, Chen Yen ; Hsu, Wei-Hsuan ; Tai, Chen Jei ; Tai, Cheng Jeng. / Polysaccharides obtained from mycelia of cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy. In: African Health Sciences. 2019 ; Vol. 19, No. 2. pp. 2156-2163.
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abstract = "Objectives: Fungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy. Methods: Doxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells. Results: PS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells. Conclusion: These findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.",
author = "Lin, {Ruo Kai} and Choong, {Chen Yen} and Wei-Hsuan Hsu and Tai, {Chen Jei} and Tai, {Cheng Jeng}",
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Polysaccharides obtained from mycelia of cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy. / Lin, Ruo Kai; Choong, Chen Yen; Hsu, Wei-Hsuan; Tai, Chen Jei; Tai, Cheng Jeng.

In: African Health Sciences, Vol. 19, No. 2, 01.06.2019, p. 2156-2163.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polysaccharides obtained from mycelia of cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy

AU - Lin, Ruo Kai

AU - Choong, Chen Yen

AU - Hsu, Wei-Hsuan

AU - Tai, Chen Jei

AU - Tai, Cheng Jeng

PY - 2019/6/1

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N2 - Objectives: Fungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy. Methods: Doxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells. Results: PS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells. Conclusion: These findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.

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