Abstract
Objectives: Fungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy. Methods: Doxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells. Results: PS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells. Conclusion: These findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 2156-2163 |
| Number of pages | 8 |
| Journal | African Health Sciences |
| Volume | 19 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2019 Jun 1 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Polysaccharides obtained from mycelia of cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy. / Lin, Ruo Kai; Choong, Chen Yen; Hsu, Wei-Hsuan; Tai, Chen Jei; Tai, Cheng Jeng.
In: African Health Sciences, Vol. 19, No. 2, 01.06.2019, p. 2156-2163.Research output: Contribution to journal › Article
TY - JOUR
T1 - Polysaccharides obtained from mycelia of cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy
AU - Lin, Ruo Kai
AU - Choong, Chen Yen
AU - Hsu, Wei-Hsuan
AU - Tai, Chen Jei
AU - Tai, Cheng Jeng
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Objectives: Fungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy. Methods: Doxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells. Results: PS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells. Conclusion: These findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.
AB - Objectives: Fungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy. Methods: Doxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells. Results: PS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells. Conclusion: These findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.
UR - http://www.scopus.com/inward/record.url?scp=85071695276&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071695276&partnerID=8YFLogxK
U2 - 10.4314/ahs.v19i2.40
DO - 10.4314/ahs.v19i2.40
M3 - Article
C2 - 31656500
AN - SCOPUS:85071695276
VL - 19
SP - 2156
EP - 2163
JO - African Health Sciences
JF - African Health Sciences
SN - 1680-6905
IS - 2
ER -