Porcine hematopoietic progenitor cell transplantation in nonhuman primates: A review of progress

Yau-Lin Tseng, David H. Sachs, David K.C. Cooper

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

The critical shortage of human donor organs for transplantation would be overcome if a suitable animal, e.g., the pig, could be used as an organ source. There are, however, several immune barriers that have to date resulted in limited function of pig organs transplanted into nonhuman primates. It would be beneficial, and indeed may be essential, to induce a state of tolerance in the primate recipient to the pig organ. In allotransplantation, the successful transplantation of hematopoietic progenitor cells with the development of mixed chimerism is associated with the induction of tolerance toward a donor-specific organ. For some years, this approach has been explored in the pig-to-nonhuman primate model. This experience is briefly reviewed. The problems of natural and elicited anti-pig antibodies, recipient platelet adhesion to pig hematopietic progenitor cells, and the rapid removal of these cells by the host macrophage-phagocytic system are highlighted. Recent experience with the use of hematopoietic cells from pigs homozygous for α1,3-galactosyltransferase gene-knockout is reported.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalTransplantation
Volume79
Issue number1
DOIs
Publication statusPublished - 2005 Jan 15

Fingerprint

Cell Transplantation
Hematopoietic Stem Cells
Primates
Swine
Tissue Donors
Galactosyltransferases
Gene Knockout Techniques
Chimerism
Organ Transplantation
Anti-Idiotypic Antibodies
Stem Cells
Blood Platelets
Transplantation
Macrophages

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

@article{5e3a677e261e441a83090bdfec7209f1,
title = "Porcine hematopoietic progenitor cell transplantation in nonhuman primates: A review of progress",
abstract = "The critical shortage of human donor organs for transplantation would be overcome if a suitable animal, e.g., the pig, could be used as an organ source. There are, however, several immune barriers that have to date resulted in limited function of pig organs transplanted into nonhuman primates. It would be beneficial, and indeed may be essential, to induce a state of tolerance in the primate recipient to the pig organ. In allotransplantation, the successful transplantation of hematopoietic progenitor cells with the development of mixed chimerism is associated with the induction of tolerance toward a donor-specific organ. For some years, this approach has been explored in the pig-to-nonhuman primate model. This experience is briefly reviewed. The problems of natural and elicited anti-pig antibodies, recipient platelet adhesion to pig hematopietic progenitor cells, and the rapid removal of these cells by the host macrophage-phagocytic system are highlighted. Recent experience with the use of hematopoietic cells from pigs homozygous for α1,3-galactosyltransferase gene-knockout is reported.",
author = "Yau-Lin Tseng and Sachs, {David H.} and Cooper, {David K.C.}",
year = "2005",
month = "1",
day = "15",
doi = "10.1097/01.TP.0000146504.73727.13",
language = "English",
volume = "79",
pages = "1--9",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

Porcine hematopoietic progenitor cell transplantation in nonhuman primates : A review of progress. / Tseng, Yau-Lin; Sachs, David H.; Cooper, David K.C.

In: Transplantation, Vol. 79, No. 1, 15.01.2005, p. 1-9.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Porcine hematopoietic progenitor cell transplantation in nonhuman primates

T2 - A review of progress

AU - Tseng, Yau-Lin

AU - Sachs, David H.

AU - Cooper, David K.C.

PY - 2005/1/15

Y1 - 2005/1/15

N2 - The critical shortage of human donor organs for transplantation would be overcome if a suitable animal, e.g., the pig, could be used as an organ source. There are, however, several immune barriers that have to date resulted in limited function of pig organs transplanted into nonhuman primates. It would be beneficial, and indeed may be essential, to induce a state of tolerance in the primate recipient to the pig organ. In allotransplantation, the successful transplantation of hematopoietic progenitor cells with the development of mixed chimerism is associated with the induction of tolerance toward a donor-specific organ. For some years, this approach has been explored in the pig-to-nonhuman primate model. This experience is briefly reviewed. The problems of natural and elicited anti-pig antibodies, recipient platelet adhesion to pig hematopietic progenitor cells, and the rapid removal of these cells by the host macrophage-phagocytic system are highlighted. Recent experience with the use of hematopoietic cells from pigs homozygous for α1,3-galactosyltransferase gene-knockout is reported.

AB - The critical shortage of human donor organs for transplantation would be overcome if a suitable animal, e.g., the pig, could be used as an organ source. There are, however, several immune barriers that have to date resulted in limited function of pig organs transplanted into nonhuman primates. It would be beneficial, and indeed may be essential, to induce a state of tolerance in the primate recipient to the pig organ. In allotransplantation, the successful transplantation of hematopoietic progenitor cells with the development of mixed chimerism is associated with the induction of tolerance toward a donor-specific organ. For some years, this approach has been explored in the pig-to-nonhuman primate model. This experience is briefly reviewed. The problems of natural and elicited anti-pig antibodies, recipient platelet adhesion to pig hematopietic progenitor cells, and the rapid removal of these cells by the host macrophage-phagocytic system are highlighted. Recent experience with the use of hematopoietic cells from pigs homozygous for α1,3-galactosyltransferase gene-knockout is reported.

UR - http://www.scopus.com/inward/record.url?scp=12344328358&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12344328358&partnerID=8YFLogxK

U2 - 10.1097/01.TP.0000146504.73727.13

DO - 10.1097/01.TP.0000146504.73727.13

M3 - Review article

C2 - 15714161

AN - SCOPUS:12344328358

VL - 79

SP - 1

EP - 9

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 1

ER -