Porous iron oxide based nanorods developed as delivery nanocapsules

Ping Ching Wu, Wen Shiuan Wang, Ying Ting Huang, Hwo Shuenn Sheu, Yi Wei Lo, Tsung Lin Tsai, Dar Bin Shieh, Chen Sheng Yeh

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)

Abstract

A low-temperature solution approach (90-95°C) using FeCl3 and urea was carried out to synthesize β-FeOOH nanorods in aqueous solution. The as-synthesized β-FeOOH nanorods were further calcined at 300°C to form porous nanorods with compositions including both β-FeOOH and α-Fe2O3. The derived porous nanorods were engineered to assemble with four layers of polyelectrolytes (polyacrylic acid (PAA)/polyethylenimine(PEI)/PAA/PEI) on their surfaces as polyelectrolyte multilayer nanocapsules. Fluorescein isothiocyanate (FITC) molecules were loaded into the polyelectrolyte multilayer nanocapsules in order to investigate drug release and intracellular delivery in Hela cells. The as-prepared nanocapsules showed ionic strength-dependent control of the permeability of the polyelectrolyte shells. The release behavior of the entrapped FITC from the FITC-loaded nanocapsules exhibited either controlled- or sustained-release trends, depending on the compactness of the polyelectrolyte shells on the nanorod surfaces. Cytotoxicity measurements demonstrate that the native nanorods and the polymer-coated nanorods have excellent bio-compatibility in ail dosages between 0.1 ng mL-1 and 100 μgm L-1. The time dependence of uptake of FITC-loaded nanocapsules by Hela cancer cells ob served by laser confocal microscopy in dicates that the nanocapsules can readily be taken up by cancer cells in 15 min, a relatively short period of time, while the slow release of the FITC from the initial perimembrane space into the cytoplasm was followed by release into the nucleus after 24 h.

Original languageEnglish
Pages (from-to)3878-3885
Number of pages8
JournalChemistry - A European Journal
Volume13
Issue number14
DOIs
Publication statusPublished - 2007 Jun 21

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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