Portable electrochemical sensing system with molecularly imprinted electrochemical sensing for biomolecular detection

Wei Chiun Liu, Bin-Da Liu, Jing Jou Tang

Research output: Contribution to journalArticle

Abstract

This paper presents a low-cost, flexible, and portable electrochemical sensing platform for biomedical in vitro diagnostic applications. This proposed system automatically measures the redox current, which depends on the concentration of the target molecule in the analyte solution; it can estimate the concentration of analytes and finds applications in biomedical sensing. The target molecule is imprinted into poly(ethylene-co-vinyl alcohol), which is coated on the surface of a screen-printed electrode. Melatonin is used as the target molecule for this system. The level of melatonin secreted in the urine might be associated with breast cancer risks. The measurement results of this system were compared with those of a commercial analyzer and were found to be very similar. This system can be operated independently and can be connected to a laptop for viewing the redox reaction by using the LabVIEW program, which provides a convenient graphical user interface for real-time monitoring and recording the information of electrochemical reactions. Compared with the results of the enzyme-linked immune sorbent assay in the urine sample measurement, those of the proposed system has moderate accuracy for urinary melatonin detection.

Original languageEnglish
Pages (from-to)89-97
Number of pages9
JournalInternational Journal of Electrical Engineering
Volume26
Issue number2
DOIs
Publication statusPublished - 2019 Apr 1

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Molecules
Redox reactions
Graphical user interfaces
Sorbents
Assays
Ethylene
Alcohols
Enzymes
Electrodes
Monitoring
Melatonin
Costs
Oxidation-Reduction

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

Cite this

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Portable electrochemical sensing system with molecularly imprinted electrochemical sensing for biomolecular detection. / Liu, Wei Chiun; Liu, Bin-Da; Tang, Jing Jou.

In: International Journal of Electrical Engineering, Vol. 26, No. 2, 01.04.2019, p. 89-97.

Research output: Contribution to journalArticle

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