Portable potentiostatic sensor integrated with neopterin-imprinted poly(ethylene-co-vinyl alcohol)-based electrode

C. Y. Huang, C. H. Hsieh, Y. L. Chen, M. H. Lee, C. F. Lin, H. H. Tsai, Y. Z. Juang, Bin-Da Liu, H. Y. Lin

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Neopterin is a catabolic product of guanosine triphosphate, a purine nucleotide. Measuring neopterin concentrations in biological fluids such as urine provides information about cellular immune activation in humans under control of T helper cells. A high neopterin concentration in bodily fluids, including serum and urine, indicates cellular immunity activation, which is associated with oxidative stress. In this work, neopterin is the target molecule and imprinted onto poly(ethylene-co-vinyl alcohol) via solvent evaporation. The template molecules on the thin film are then removed, and the membrane is used as a sensing element for electrochemical urinalysis. Poly(ethylene-co-vinyl alcohol) containing 27mol ethylene had high imprinting effectiveness and may be integrated with the proposed portable biosensor. In random urine analysis, the cyclic voltammetry measurements of neopterin with an additional recovery method achieved >95 recovery for the neopterin concentration of 15ng/mL.

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalIET Nanobiotechnology
Issue number4
Publication statusPublished - 2011 Dec 1

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biotechnology
  • Electrical and Electronic Engineering

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