TY - JOUR
T1 - Portable ultraviolet light A1 light source to treat hypertrophic scar
AU - Huang, Yen Chen
AU - Huang, Chin Te
AU - Hu, Chieh
AU - Wong, Tak Wah
N1 - Publisher Copyright:
© 2014, Taiwanese Dermatological Association.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Background/Objectives Recently, fibrotic diseases such as hypertrophic scar, keloid, and scleroderma have been treated with UV-A1 radiation with encouraging results. However, conventional UV light sources are bulky and expensive. In this study, we aimed to verify the effectiveness of a portable UV-A1 radiation device in treating hypertrophic scars. Materials and methods A light-emitting diode array that emitted 365 ± 5 nm (UV-A1) was used to irradiate fibroblasts and hypertrophic scar in a rabbit model. Results In cell cultures, UV-A1 light exposure inhibited post-wound cell migration and reduced the total amount of soluble collagen production in fibroblasts. Type I collagenase production and its activity increased after treatment. On the rabbit ear, UV-A1 light irradiation reduced the thickness of hypertrophic scars, confirming the antifibrotic effect in vivo. Conclusion These results support the potential of a portable UV-A1 light device in treating hypertrophic scar.
AB - Background/Objectives Recently, fibrotic diseases such as hypertrophic scar, keloid, and scleroderma have been treated with UV-A1 radiation with encouraging results. However, conventional UV light sources are bulky and expensive. In this study, we aimed to verify the effectiveness of a portable UV-A1 radiation device in treating hypertrophic scars. Materials and methods A light-emitting diode array that emitted 365 ± 5 nm (UV-A1) was used to irradiate fibroblasts and hypertrophic scar in a rabbit model. Results In cell cultures, UV-A1 light exposure inhibited post-wound cell migration and reduced the total amount of soluble collagen production in fibroblasts. Type I collagenase production and its activity increased after treatment. On the rabbit ear, UV-A1 light irradiation reduced the thickness of hypertrophic scars, confirming the antifibrotic effect in vivo. Conclusion These results support the potential of a portable UV-A1 light device in treating hypertrophic scar.
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U2 - 10.1016/j.dsi.2014.10.001
DO - 10.1016/j.dsi.2014.10.001
M3 - Article
AN - SCOPUS:84921438807
SN - 1027-8117
VL - 33
SP - 11
EP - 15
JO - Dermatologica Sinica
JF - Dermatologica Sinica
IS - 1
ER -