Positive blood culture is not associated with increased mortality in patients with sepsis-induced acute respiratory distress syndrome

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and objective Previous studies have demonstrated that positive blood culture could contribute to poorer outcomes in patients with pneumonia. However, the impact of positive blood culture on the outcomes of patients with sepsis-induced acute respiratory distress syndrome (ARDS) has not been evaluated. Methods An observational study that prospectively screened 4861 patients admitted to medical or surgical intensive care units (ICUs) of a tertiary referral centre was performed. Results Among 4861 admitted patients, 146 diagnosed with sepsis-induced ARDS were enrolled (mean age: 66.1 years). Lower PaO2/FiO2, decreased respiratory system compliance, and higher lung injury scores (LIS) on the day of ARDS diagnosis were associated with positive blood cultures (n = 68) rather than negative blood cultures (n = 78). There was no relationship between positive blood culture and in-hospital mortality. Kaplan-Meier estimates also revealed that positive blood culture was not associated with 60-day mortality but with an increased length of stay in the hospital and in the ICU (P = 0.007 and P = 0.016, respectively). Using multivariate logistic regression, higher LIS was independently associated with positive blood culture. In addition, chronic pulmonary disease, lower platelet count, higher LIS, and the development of shock on the diagnosis of ARDS, were independent risk factors for in-hospital mortality. Conclusions This study suggests that the presence of positive blood culture is not associated with increased mortality; however, the mean durations of hospital and ICU stays in patients with sepsis-induced ARDS are increased. We evaluated the relationship between positive blood culture and the outcomes of sepsis-induced ARDS. We found that positive blood culture was not associated with increased mortality. However, the mean durations of hospital and intensive care unit stays in patients with sepsis-induced ARDS were increased.

Original languageEnglish
Pages (from-to)1210-1216
Number of pages7
JournalRespirology
Volume18
Issue number8
DOIs
Publication statusPublished - 2013 Nov

Fingerprint

Adult Respiratory Distress Syndrome
Sepsis
Mortality
Intensive Care Units
Lung Injury
Hospital Mortality
Blood Culture
Kaplan-Meier Estimate
Critical Care
Platelet Count
Tertiary Care Centers
Respiratory System
Lung Diseases
Compliance
Observational Studies
Shock
Length of Stay
Pneumonia
Chronic Disease
Logistic Models

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

@article{129862fc27834df9991076fa104adc72,
title = "Positive blood culture is not associated with increased mortality in patients with sepsis-induced acute respiratory distress syndrome",
abstract = "Background and objective Previous studies have demonstrated that positive blood culture could contribute to poorer outcomes in patients with pneumonia. However, the impact of positive blood culture on the outcomes of patients with sepsis-induced acute respiratory distress syndrome (ARDS) has not been evaluated. Methods An observational study that prospectively screened 4861 patients admitted to medical or surgical intensive care units (ICUs) of a tertiary referral centre was performed. Results Among 4861 admitted patients, 146 diagnosed with sepsis-induced ARDS were enrolled (mean age: 66.1 years). Lower PaO2/FiO2, decreased respiratory system compliance, and higher lung injury scores (LIS) on the day of ARDS diagnosis were associated with positive blood cultures (n = 68) rather than negative blood cultures (n = 78). There was no relationship between positive blood culture and in-hospital mortality. Kaplan-Meier estimates also revealed that positive blood culture was not associated with 60-day mortality but with an increased length of stay in the hospital and in the ICU (P = 0.007 and P = 0.016, respectively). Using multivariate logistic regression, higher LIS was independently associated with positive blood culture. In addition, chronic pulmonary disease, lower platelet count, higher LIS, and the development of shock on the diagnosis of ARDS, were independent risk factors for in-hospital mortality. Conclusions This study suggests that the presence of positive blood culture is not associated with increased mortality; however, the mean durations of hospital and ICU stays in patients with sepsis-induced ARDS are increased. We evaluated the relationship between positive blood culture and the outcomes of sepsis-induced ARDS. We found that positive blood culture was not associated with increased mortality. However, the mean durations of hospital and intensive care unit stays in patients with sepsis-induced ARDS were increased.",
author = "Seu-Chun Yang and Liao, {Kuang Ming} and Chang-Wen Chen and Wei-Chieh Lin",
year = "2013",
month = "11",
doi = "10.1111/resp.12121",
language = "English",
volume = "18",
pages = "1210--1216",
journal = "Respirology",
issn = "1323-7799",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Positive blood culture is not associated with increased mortality in patients with sepsis-induced acute respiratory distress syndrome

AU - Yang, Seu-Chun

AU - Liao, Kuang Ming

AU - Chen, Chang-Wen

AU - Lin, Wei-Chieh

PY - 2013/11

Y1 - 2013/11

N2 - Background and objective Previous studies have demonstrated that positive blood culture could contribute to poorer outcomes in patients with pneumonia. However, the impact of positive blood culture on the outcomes of patients with sepsis-induced acute respiratory distress syndrome (ARDS) has not been evaluated. Methods An observational study that prospectively screened 4861 patients admitted to medical or surgical intensive care units (ICUs) of a tertiary referral centre was performed. Results Among 4861 admitted patients, 146 diagnosed with sepsis-induced ARDS were enrolled (mean age: 66.1 years). Lower PaO2/FiO2, decreased respiratory system compliance, and higher lung injury scores (LIS) on the day of ARDS diagnosis were associated with positive blood cultures (n = 68) rather than negative blood cultures (n = 78). There was no relationship between positive blood culture and in-hospital mortality. Kaplan-Meier estimates also revealed that positive blood culture was not associated with 60-day mortality but with an increased length of stay in the hospital and in the ICU (P = 0.007 and P = 0.016, respectively). Using multivariate logistic regression, higher LIS was independently associated with positive blood culture. In addition, chronic pulmonary disease, lower platelet count, higher LIS, and the development of shock on the diagnosis of ARDS, were independent risk factors for in-hospital mortality. Conclusions This study suggests that the presence of positive blood culture is not associated with increased mortality; however, the mean durations of hospital and ICU stays in patients with sepsis-induced ARDS are increased. We evaluated the relationship between positive blood culture and the outcomes of sepsis-induced ARDS. We found that positive blood culture was not associated with increased mortality. However, the mean durations of hospital and intensive care unit stays in patients with sepsis-induced ARDS were increased.

AB - Background and objective Previous studies have demonstrated that positive blood culture could contribute to poorer outcomes in patients with pneumonia. However, the impact of positive blood culture on the outcomes of patients with sepsis-induced acute respiratory distress syndrome (ARDS) has not been evaluated. Methods An observational study that prospectively screened 4861 patients admitted to medical or surgical intensive care units (ICUs) of a tertiary referral centre was performed. Results Among 4861 admitted patients, 146 diagnosed with sepsis-induced ARDS were enrolled (mean age: 66.1 years). Lower PaO2/FiO2, decreased respiratory system compliance, and higher lung injury scores (LIS) on the day of ARDS diagnosis were associated with positive blood cultures (n = 68) rather than negative blood cultures (n = 78). There was no relationship between positive blood culture and in-hospital mortality. Kaplan-Meier estimates also revealed that positive blood culture was not associated with 60-day mortality but with an increased length of stay in the hospital and in the ICU (P = 0.007 and P = 0.016, respectively). Using multivariate logistic regression, higher LIS was independently associated with positive blood culture. In addition, chronic pulmonary disease, lower platelet count, higher LIS, and the development of shock on the diagnosis of ARDS, were independent risk factors for in-hospital mortality. Conclusions This study suggests that the presence of positive blood culture is not associated with increased mortality; however, the mean durations of hospital and ICU stays in patients with sepsis-induced ARDS are increased. We evaluated the relationship between positive blood culture and the outcomes of sepsis-induced ARDS. We found that positive blood culture was not associated with increased mortality. However, the mean durations of hospital and intensive care unit stays in patients with sepsis-induced ARDS were increased.

UR - http://www.scopus.com/inward/record.url?scp=84886816007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886816007&partnerID=8YFLogxK

U2 - 10.1111/resp.12121

DO - 10.1111/resp.12121

M3 - Article

VL - 18

SP - 1210

EP - 1216

JO - Respirology

JF - Respirology

SN - 1323-7799

IS - 8

ER -