Possible Epistatic Role of ADH7 in the Protection Against Alcoholism

M. V. Osier, R. B. Lu, A. J. Pakstis, J. R. Kidd, S. Y. Huang, Kenneth K. Kidd

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His. Here we present evidence for an additional effect from outside the Class I ADH genes, presumably from functional variation at the ADH7 gene. The protective effect is restricted to one of two haplotypes identical at ADH1B but differing at an intronic SNP at ADH7 suggesting epistasis or strong linkage disequilibrium (LD).

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume126 B
Issue number1
Publication statusPublished - 2004 Apr 1

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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