Possible Epistatic Role of ADH7 in the Protection Against Alcoholism

TY - JOUR

T1 - Possible Epistatic Role of ADH7 in the Protection Against Alcoholism

AU - Osier, M. V.

AU - Lu, R. B.

AU - Pakstis, A. J.

AU - Kidd, J. R.

AU - Huang, S. Y.

AU - Kidd, Kenneth K.

PY - 2004/4/1

Y1 - 2004/4/1

N2 - In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His. Here we present evidence for an additional effect from outside the Class I ADH genes, presumably from functional variation at the ADH7 gene. The protective effect is restricted to one of two haplotypes identical at ADH1B but differing at an intronic SNP at ADH7 suggesting epistasis or strong linkage disequilibrium (LD).

AB - In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His. Here we present evidence for an additional effect from outside the Class I ADH genes, presumably from functional variation at the ADH7 gene. The protective effect is restricted to one of two haplotypes identical at ADH1B but differing at an intronic SNP at ADH7 suggesting epistasis or strong linkage disequilibrium (LD).

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M3 - Article

C2 - 15048643

AN - SCOPUS:1842487423

SN - 1552-4841

VL - 126 B

SP - 19

EP - 22

JO - American Journal of Medical Genetics - Neuropsychiatric Genetics

JF - American Journal of Medical Genetics - Neuropsychiatric Genetics

IS - 1

ER -