TY - JOUR
T1 - Potent α-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major
AU - Chan, Hsiu Hui
AU - Sun, Han Dong
AU - Reddy, Mopur Vijaya Bhaskar
AU - Wu, Tian Shung
N1 - Funding Information:
The authors are grateful for financial support from the National Science Council of Republic of China awarded to T.-S. Wu.
PY - 2010/8
Y1 - 2010/8
N2 - Bioassay-guided fractionation of the CHCl3 soluble portion of the roots of Panax japonicus C. A. Meyer var. major afforded an active fraction with inhibitory activity against baker's yeast α-glucosidase with an IC50 value 1.02 mg/mL. Furthermore, the active fraction isolated contained three previously unreported polyacetylenes, designated panaxjapynes A-C, together with 11 other compounds, including four polyacetylenes, five phenolic compounds, a sesquiterpenoid, and a sterol glucoside. The structures of the compounds were elucidated by spectroscopic and chemical methods. Compared with the control acarbose (IC50 677.97 μM), six compounds were shown to be more potent α-glucosidase inhibitors with IC50 values in the range 22.21-217.68 μM.
AB - Bioassay-guided fractionation of the CHCl3 soluble portion of the roots of Panax japonicus C. A. Meyer var. major afforded an active fraction with inhibitory activity against baker's yeast α-glucosidase with an IC50 value 1.02 mg/mL. Furthermore, the active fraction isolated contained three previously unreported polyacetylenes, designated panaxjapynes A-C, together with 11 other compounds, including four polyacetylenes, five phenolic compounds, a sesquiterpenoid, and a sterol glucoside. The structures of the compounds were elucidated by spectroscopic and chemical methods. Compared with the control acarbose (IC50 677.97 μM), six compounds were shown to be more potent α-glucosidase inhibitors with IC50 values in the range 22.21-217.68 μM.
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U2 - 10.1016/j.phytochem.2010.04.013
DO - 10.1016/j.phytochem.2010.04.013
M3 - Article
C2 - 20493502
AN - SCOPUS:77954243736
SN - 0031-9422
VL - 71
SP - 1360
EP - 1364
JO - Phytochemistry
JF - Phytochemistry
IS - 11-12
ER -