Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-α production in mouse macrophages

Shiow Hwa Day; Yi Chen Lin; Mei Lin Tsai; Lo Ti Tsao; Horng Huey Ko; Mei Ing Chung; Jeng Chang Lee; Jih Pyang Wang; Shen Jeu Won; Chun Nan Lin

doi:10.1021/np0101651

Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-α production in mouse macrophages

Shiow Hwa Day, Yi Chen Lin, Mei Lin Tsai, Lo Ti Tsao, Horng Huey Ko, Mei Ing Chung, Jeng Chang Lee, Jih Pyang Wang, Shen Jeu Won, Chun Nan Lin

Department of Surgery

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Abstract

A new lignan glycoside, 4-O-α-L-arabinopyranosyl-(1‴→2″)-β-D- apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens. The structure of 2 was established by spectral analysis and chemical methods. The known compounds justicidin A (1), diphyllin (3), and tuberculatin (4) showed potent cytotoxic effects against a number of cancer cells in vitro. Compounds 1 and 4 also strongly enhanced tumor-necrosis factor-α (TNF-α) generation from mouse macrophage-like RAW 264.7 cells stimulated with lipopolysaccharide (LPS).

Original language	English
Pages (from-to)	379-381
Number of pages	3
Journal	Journal of Natural Products
Volume	65
Issue number	3
DOIs	https://doi.org/10.1021/np0101651
Publication status	Published - 2002

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np0101651

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title = "Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-α production in mouse macrophages",

abstract = "A new lignan glycoside, 4-O-α-L-arabinopyranosyl-(1‴→2″)-β-D- apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens. The structure of 2 was established by spectral analysis and chemical methods. The known compounds justicidin A (1), diphyllin (3), and tuberculatin (4) showed potent cytotoxic effects against a number of cancer cells in vitro. Compounds 1 and 4 also strongly enhanced tumor-necrosis factor-α (TNF-α) generation from mouse macrophage-like RAW 264.7 cells stimulated with lipopolysaccharide (LPS).",

author = "Day, {Shiow Hwa} and Lin, {Yi Chen} and Tsai, {Mei Lin} and Tsao, {Lo Ti} and Ko, {Horng Huey} and Chung, {Mei Ing} and Lee, {Jeng Chang} and Wang, {Jih Pyang} and Won, {Shen Jeu} and Lin, {Chun Nan}",

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doi = "10.1021/np0101651",

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pages = "379--381",

journal = "Journal of Natural Products",

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T1 - Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-α production in mouse macrophages

AU - Day, Shiow Hwa

AU - Lin, Yi Chen

AU - Tsai, Mei Lin

AU - Tsao, Lo Ti

AU - Ko, Horng Huey

AU - Chung, Mei Ing

AU - Lee, Jeng Chang

AU - Wang, Jih Pyang

AU - Won, Shen Jeu

AU - Lin, Chun Nan

PY - 2002

Y1 - 2002

N2 - A new lignan glycoside, 4-O-α-L-arabinopyranosyl-(1‴→2″)-β-D- apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens. The structure of 2 was established by spectral analysis and chemical methods. The known compounds justicidin A (1), diphyllin (3), and tuberculatin (4) showed potent cytotoxic effects against a number of cancer cells in vitro. Compounds 1 and 4 also strongly enhanced tumor-necrosis factor-α (TNF-α) generation from mouse macrophage-like RAW 264.7 cells stimulated with lipopolysaccharide (LPS).

AB - A new lignan glycoside, 4-O-α-L-arabinopyranosyl-(1‴→2″)-β-D- apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens. The structure of 2 was established by spectral analysis and chemical methods. The known compounds justicidin A (1), diphyllin (3), and tuberculatin (4) showed potent cytotoxic effects against a number of cancer cells in vitro. Compounds 1 and 4 also strongly enhanced tumor-necrosis factor-α (TNF-α) generation from mouse macrophage-like RAW 264.7 cells stimulated with lipopolysaccharide (LPS).

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Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-α production in mouse macrophages

Abstract

All Science Journal Classification (ASJC) codes

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