Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-α production in mouse macrophages

Shiow Hwa Day, Yi Chen Lin, Mei Lin Tsai, Lo Ti Tsao, Horng Huey Ko, Mei Ing Chung, Jeng Chang Lee, Jih Pyang Wang, Shen Jeu Won, Chun Nan Lin

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

A new lignan glycoside, 4-O-α-L-arabinopyranosyl-(1‴→2″)-β-D- apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens. The structure of 2 was established by spectral analysis and chemical methods. The known compounds justicidin A (1), diphyllin (3), and tuberculatin (4) showed potent cytotoxic effects against a number of cancer cells in vitro. Compounds 1 and 4 also strongly enhanced tumor-necrosis factor-α (TNF-α) generation from mouse macrophage-like RAW 264.7 cells stimulated with lipopolysaccharide (LPS).

Original languageEnglish
Pages (from-to)379-381
Number of pages3
JournalJournal of Natural Products
Volume65
Issue number3
DOIs
Publication statusPublished - 2002 Apr 9

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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