Potential application of the D-amino acid oxidase (DAAO) inhibitor sodium benzoate for individuals experiencing psychological stress after traumatic events

Preventing post-traumatic stress disorder (PTSD), which is harmful in terms of human resources and burdens society, is an urgent issue. The glutamatergic system, a newly-identified target site of recent pharmacological interventions for various mental disorders, could be a potential pathway. A recent study confirmed that sodium benzoate, which is a D-amino acid oxidase (DAAO) inhibitor that is used as a safe food additive, is therapeutically effective for certain mental disorders. Studies also indicated a medium effect size on the perceived stress and 28%-61% reduction of panic symptoms. Hereby, we propose a novel clinically oriented medical idea: “proper use of sodium benzoate in the preparation of rations for individuals with mental disorders who will be or are currently exposed to stressors could be a feasible method for preventing PTSD and other associated mental disorders”. While this idea remains to be tested, its application could be helpful for rescue workers or victims of disaster.