Potential of aspirin to inhibit thrombotic microangiopathy in α1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons

F. J.M.F. Dor; K. Kuwaki; Y. L. Tseng; A. Shimizu; S. L. Houser; K. Yamada; R. J. Hawley; C. Patience; M. Awwad; J. A. Fishman; S. C. Robson; D. H. Sachs; H. J. Schuurman; D. K.C. Cooper

doi:10.1016/j.transproceed.2004.12.235

Potential of aspirin to inhibit thrombotic microangiopathy in α1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons

F. J.M.F. Dor, K. Kuwaki, Y. L. Tseng, A. Shimizu, S. L. Houser, K. Yamada, R. J. Hawley, C. Patience, M. Awwad, J. A. Fishman, S. C. Robson, D. H. Sachs, H. J. Schuurman, D. K.C. Cooper

Department of Surgery

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Hearts from α1,3-Galactosyltransferase gene-knockout (GaIT-KO) pigs were transplanted heterotopically into 8 baboons that received an anti-CD154 monoclonal antibody (mAb)-based immunosuppressive regimen and heparin. Three baboons died or were euthanized with beating grafts on 16, 23, and 56 days, respectively, and the remaining 5 grafts functioned for 59-179 days. Hyperacute rejection did not occur, and classical features of acute humoral xenograft or acute cellular rejection were rare. However, thrombotic microangiopathy (TM) developed in all cases; its onset was delayed in 2 baboons that received aspirin. Function of a pig organ in a baboon for a period approaching 6 months has not been reported previously and lends encouragement that the barriers to xenotransplantation will be overcome, but TM requires investigation.

Original language	English
Pages (from-to)	489-490
Number of pages	2
Journal	Transplantation Proceedings
Volume	37
Issue number	1
DOIs	https://doi.org/10.1016/j.transproceed.2004.12.235
Publication status	Published - 2005

All Science Journal Classification (ASJC) codes

Surgery
Transplantation

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Dor, F. J. M. F., Kuwaki, K., Tseng, Y. L., Shimizu, A., Houser, S. L., Yamada, K., Hawley, R. J., Patience, C., Awwad, M., Fishman, J. A., Robson, S. C., Sachs, D. H., Schuurman, H. J., & Cooper, D. K. C. (2005). Potential of aspirin to inhibit thrombotic microangiopathy in α1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons. Transplantation Proceedings, 37(1), 489-490. https://doi.org/10.1016/j.transproceed.2004.12.235

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title = "Potential of aspirin to inhibit thrombotic microangiopathy in α1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons",

abstract = "Hearts from α1,3-Galactosyltransferase gene-knockout (GaIT-KO) pigs were transplanted heterotopically into 8 baboons that received an anti-CD154 monoclonal antibody (mAb)-based immunosuppressive regimen and heparin. Three baboons died or were euthanized with beating grafts on 16, 23, and 56 days, respectively, and the remaining 5 grafts functioned for 59-179 days. Hyperacute rejection did not occur, and classical features of acute humoral xenograft or acute cellular rejection were rare. However, thrombotic microangiopathy (TM) developed in all cases; its onset was delayed in 2 baboons that received aspirin. Function of a pig organ in a baboon for a period approaching 6 months has not been reported previously and lends encouragement that the barriers to xenotransplantation will be overcome, but TM requires investigation.",

author = "Dor, {F. J.M.F.} and K. Kuwaki and Tseng, {Y. L.} and A. Shimizu and Houser, {S. L.} and K. Yamada and Hawley, {R. J.} and C. Patience and M. Awwad and Fishman, {J. A.} and Robson, {S. C.} and Sachs, {D. H.} and Schuurman, {H. J.} and Cooper, {D. K.C.}",

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Dor, FJMF, Kuwaki, K, Tseng, YL, Shimizu, A, Houser, SL, Yamada, K, Hawley, RJ, Patience, C, Awwad, M, Fishman, JA, Robson, SC, Sachs, DH, Schuurman, HJ & Cooper, DKC 2005, 'Potential of aspirin to inhibit thrombotic microangiopathy in α1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons', Transplantation Proceedings, vol. 37, no. 1, pp. 489-490. https://doi.org/10.1016/j.transproceed.2004.12.235

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AU - Dor, F. J.M.F.

AU - Kuwaki, K.

AU - Tseng, Y. L.

AU - Shimizu, A.

AU - Houser, S. L.

AU - Yamada, K.

AU - Hawley, R. J.

AU - Patience, C.

AU - Awwad, M.

AU - Fishman, J. A.

AU - Robson, S. C.

AU - Sachs, D. H.

AU - Schuurman, H. J.

AU - Cooper, D. K.C.

PY - 2005

Y1 - 2005

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AB - Hearts from α1,3-Galactosyltransferase gene-knockout (GaIT-KO) pigs were transplanted heterotopically into 8 baboons that received an anti-CD154 monoclonal antibody (mAb)-based immunosuppressive regimen and heparin. Three baboons died or were euthanized with beating grafts on 16, 23, and 56 days, respectively, and the remaining 5 grafts functioned for 59-179 days. Hyperacute rejection did not occur, and classical features of acute humoral xenograft or acute cellular rejection were rare. However, thrombotic microangiopathy (TM) developed in all cases; its onset was delayed in 2 baboons that received aspirin. Function of a pig organ in a baboon for a period approaching 6 months has not been reported previously and lends encouragement that the barriers to xenotransplantation will be overcome, but TM requires investigation.

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Potential of aspirin to inhibit thrombotic microangiopathy in α1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons

Abstract

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