Potentiation of N-methyl-D-aspartate currents by isoproterenol in the acutely dissociated rat amygdalar neurons

Chiung Chun Huang, Chih Hung Lin, Po Wu Gean

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Whole-cell patch-clamp recordings in the acutely dissociated amygdalar neurons were performed to investigate the effect of isoproterenol (Iso) on NMDA currents. Bath application of Iso selectively enhanced the NMDA currents without affecting the AMPA currents. Iso potentiated the NMDA currents to the same extent at various holding potentials and the reversal potential for the NMDA response was not altered. These results suggest that adrenergic innvervations in this area may play an important role in synaptic plasticity.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalNeuroscience Letters
Volume253
Issue number1
DOIs
Publication statusPublished - 1998 Aug 28

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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