Potentiation of N-methyl-D-aspartate currents by isoproterenol in the acutely dissociated rat amygdalar neurons

Chiung Chun Huang; Chih Hung Lin; Po Wu Gean

doi:10.1016/S0304-3940(98)00571-0

Potentiation of N-methyl-D-aspartate currents by isoproterenol in the acutely dissociated rat amygdalar neurons

Chiung Chun Huang, Chih Hung Lin, Po Wu Gean

Department of Pharmacology

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Whole-cell patch-clamp recordings in the acutely dissociated amygdalar neurons were performed to investigate the effect of isoproterenol (Iso) on NMDA currents. Bath application of Iso selectively enhanced the NMDA currents without affecting the AMPA currents. Iso potentiated the NMDA currents to the same extent at various holding potentials and the reversal potential for the NMDA response was not altered. These results suggest that adrenergic innvervations in this area may play an important role in synaptic plasticity.

Original language	English
Pages (from-to)	9-12
Number of pages	4
Journal	Neuroscience Letters
Volume	253
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(98)00571-0
Publication status	Published - 1998 Aug 28

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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title = "Potentiation of N-methyl-D-aspartate currents by isoproterenol in the acutely dissociated rat amygdalar neurons",

abstract = "Whole-cell patch-clamp recordings in the acutely dissociated amygdalar neurons were performed to investigate the effect of isoproterenol (Iso) on NMDA currents. Bath application of Iso selectively enhanced the NMDA currents without affecting the AMPA currents. Iso potentiated the NMDA currents to the same extent at various holding potentials and the reversal potential for the NMDA response was not altered. These results suggest that adrenergic innvervations in this area may play an important role in synaptic plasticity.",

author = "Huang, {Chiung Chun} and Lin, {Chih Hung} and Gean, {Po Wu}",

note = "Funding Information: This study was supported by the National Science Council of Taiwan grant NSC86-2314-B006-002-M10.",

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AU - Huang, Chiung Chun

AU - Lin, Chih Hung

AU - Gean, Po Wu

N1 - Funding Information: This study was supported by the National Science Council of Taiwan grant NSC86-2314-B006-002-M10.

PY - 1998/8/28

Y1 - 1998/8/28

N2 - Whole-cell patch-clamp recordings in the acutely dissociated amygdalar neurons were performed to investigate the effect of isoproterenol (Iso) on NMDA currents. Bath application of Iso selectively enhanced the NMDA currents without affecting the AMPA currents. Iso potentiated the NMDA currents to the same extent at various holding potentials and the reversal potential for the NMDA response was not altered. These results suggest that adrenergic innvervations in this area may play an important role in synaptic plasticity.

AB - Whole-cell patch-clamp recordings in the acutely dissociated amygdalar neurons were performed to investigate the effect of isoproterenol (Iso) on NMDA currents. Bath application of Iso selectively enhanced the NMDA currents without affecting the AMPA currents. Iso potentiated the NMDA currents to the same extent at various holding potentials and the reversal potential for the NMDA response was not altered. These results suggest that adrenergic innvervations in this area may play an important role in synaptic plasticity.

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Potentiation of N-methyl-D-aspartate currents by isoproterenol in the acutely dissociated rat amygdalar neurons

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