Power and sample size calculation for paired recurrent events data based on robust nonparametric tests

Pei Fang Su, Chia Hua Chung, Yu Wen Wang, Yunchan Chi, Ying Ju Chang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The purpose of this paper is to develop a formula for calculating the required sample size for paired recurrent events data. The developed formula is based on robust non-parametric tests for comparing the marginal mean function of events between paired samples. This calculation can accommodate the associations among a sequence of paired recurrent event times with a specification of correlated gamma frailty variables for a proportional intensity model. We evaluate the performance of the proposed method with comprehensive simulations including the impacts of paired correlations, homogeneous or nonhomogeneous processes, marginal hazard rates, censoring rate, accrual and follow-up times, as well as the sensitivity analysis for the assumption of the frailty distribution. The use of the formula is also demonstrated using a premature infant study from the neonatal intensive care unit of a tertiary center in southern Taiwan.

Original languageEnglish
Pages (from-to)1823-1838
Number of pages16
JournalStatistics in Medicine
Volume36
Issue number11
DOIs
Publication statusPublished - 2017 May 20

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Statistics and Probability

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