Predicting Fetal Growth Restriction With Renal Volume Using 3-D Ultrasound: Efficacy Evaluation

Chiung Hsin Chang, Pei Yin Tsai, Chen Hsiang Yu, Huei Chen Ko, Fong Ming Chang

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Early detection and management of fetal growth restriction (FGR) is very important in prenatal care and daily practice, because FGR fetuses may suffer increased risk of perinatal morbidity and mortality. Renal volume (RV) might be one of the important parameters of fetal growth. Yet, no prenatal assessment of fetal RV in FGR fetuses by 3-D ultrasound (US) has been reported. We undertook a prospective and cross-sectional study using quantitative 3-D US to assess the efficacy of fetal RV in predicting FGR. All fetuses were singletons and were followed-up to delivery to determine whether they had FGR complications. In total, 221 fetuses without FGR and 28 fetuses with FGR were included. Our results showed fetal RV assessed by 3-D US can differentiate fetuses with FGR from fetuses without FGR. The best predicting threshold for FGR is at the tenth percentile of fetal RV. Using the tenth percentile as the cutoff, the efficacy of fetal RV in predicting FGR was sensitivity 96.4%, specificity 95.9%, positive predictive value 75.0%, negative predictive value 99.5% and accuracy 96.0%, respectively. Fetal RV assessed by 3-D US can be applied to detect FGR prenatally. We believe fetal RV assessment using 3-D US is a useful test in detecting fetuses with FGR. (E-mail:

Original languageEnglish
Pages (from-to)533-537
Number of pages5
JournalUltrasound in Medicine and Biology
Issue number4
Publication statusPublished - 2008 Apr 1

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

Fingerprint Dive into the research topics of 'Predicting Fetal Growth Restriction With Renal Volume Using 3-D Ultrasound: Efficacy Evaluation'. Together they form a unique fingerprint.

Cite this