Prediction of outcome in infants with congenital diaphragmatic hernia or severe diaphragmatic eventration

Chih Ta Yao, Jieh Neng Wang, Chyi-Her Lin, Cheng Nan Yeh, Ying Tai Tai, Ming Ho Wu, Jing Ming Wu

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Congenital diaphragmatic hernia (CDH) and severe congenital diaphragmatic eventration (SDE) still have high mortality. Our aims were to identify clinical prognostic factors for CDH and SDE, and to determine whether the size or area of the proximal bilateral pulmonary arteries (PA) correlate with the clinical outcome. We retrospectively analyzed medical charts of 26 patients-20 with CDH and 6 with SDE, but no obvious other associated anomalies-admitted over a 12-year period. We compared prenatal history, clinical manifestations, blood gas, and echocardiography before surgery in the survivors and the non-survivors. Ten patients (8 CDH, 2 SDE) died 2 to 16 days after birth, including 2 patients without surgery due to progressive hypoxemia. The survivors had significantly higher 1-and 5-min Apgar scores, higher the worst preductal arterial blood gas pH levels, lower oxygen indices, and lower PaCO2 (P < 0.05). The McGoon index of PA size measured by echocardiography was higher in survivors, but not statistically significant. Nakada PA index results, however, were statistically significant (93.07 ± 32.02 vs. 121.07 ± 27.08, P < 0.05) In conclusion, Apgar scores, preductal PaCO2, oxygen index, and pH level can predict prognosis in infants with CDH and SDE. The Nakada PA index, however, might be a useful prognostic marker for patients with CDH and SDE.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalActa Paediatrica Taiwanica
Volume45
Issue number3
Publication statusPublished - 2004 May 1

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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