Prediction of Uric Acid on Renal Function among Adolescents: A Ten-Year Analysis

Aims: The prevalence of hyperuricemia in adolescents is increasing with each passing year. During adolescence, hyperuricemia tends to develop into adult hyperuricemia and affects renal function. The study aims to explore the relationship between hyperuricemia values and renal function and examine predictors affecting renal function risk factors among senior high school students.

Methods: The retrospective study adopted 2011–2019 health examination database of 6597 male freshmen. The Chi-squared test, t-test, ROC curve, and logistic regression were used for analysis to find out the best cut-off points of hyperuricemia for male adolescents.

Results: The best cut-off values of uric acid were 6.5 mg/dL among male adolescents and the prevalence of hyperuricemia is 55.2% in male adolescents. Uric acid was the critical predictor of renal function and the risk of a worse eGFR (<90) in the uric acid >6.5 group was increased by 2.51 times compared with the < 6.5 group.

Conclusions: The school administrators should pay attention to the diet and body size of male adolescents and prevent obesity and diets that lead to hyperuricemia to promote health in adolescents. Adolescents with uric acid >6.5 mg/mL can be followed up if uric acid has different effects on renal function.