Predictive factors of a fulminant course in acute myocarditis

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Patients who develop fulminant myocarditis often die of sudden cardiac arrest, arrhythmia, or severe heart failure soon after onset if they do not receive percutaneous cardiopulmonary support in time. The purpose of this study was to identify the risk factors of clinical symptoms/signs or laboratory findings that could predict the fulminant course of acute myocarditis. Methods and results: Thirty-five patients (mean age 28 ± 8 years, 17 males) who had been admitted to intensive care unit with the diagnosis of acute myocarditis by clinical presentations were retrospectively recruited. They were divided into the fulminant group (n = 11) and the non-fulminant group (n = 24). Clinical features, laboratory data, and images on admission were analyzed. Overall in-hospital mortality was 17% (6/35). Mortality was higher in the fulminant group (45% vs. 4%, p = 0.027). Multivariate analysis revealed that prolongations of the QRS complex (118 ± 27 vs. 88 ± 10 ms, p = 0.048) and depressed left ventricular ejection fraction (41 ± 7% vs. 57 ± 7%, p = 0.027) were the only independent factors significantly associated with the fulminant course of acute myocarditis. Conclusion: The in-hospital mortality of acute fulminant myocarditis was high. Prolongations of the QRS complex and depressed left ventricular ejection fraction on admission were independent positive predictors for the development of acute fulminant myocarditis.

Original languageEnglish
Pages (from-to)142-145
Number of pages4
JournalInternational Journal of Cardiology
Volume109
Issue number1
DOIs
Publication statusPublished - 2006 Apr 28

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Myocarditis
Hospital Mortality
Stroke Volume
Sudden Cardiac Death
Signs and Symptoms
Intensive Care Units
Cardiac Arrhythmias
Multivariate Analysis
Heart Failure
Mortality

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Predictive factors of a fulminant course in acute myocarditis",
abstract = "Background: Patients who develop fulminant myocarditis often die of sudden cardiac arrest, arrhythmia, or severe heart failure soon after onset if they do not receive percutaneous cardiopulmonary support in time. The purpose of this study was to identify the risk factors of clinical symptoms/signs or laboratory findings that could predict the fulminant course of acute myocarditis. Methods and results: Thirty-five patients (mean age 28 ± 8 years, 17 males) who had been admitted to intensive care unit with the diagnosis of acute myocarditis by clinical presentations were retrospectively recruited. They were divided into the fulminant group (n = 11) and the non-fulminant group (n = 24). Clinical features, laboratory data, and images on admission were analyzed. Overall in-hospital mortality was 17{\%} (6/35). Mortality was higher in the fulminant group (45{\%} vs. 4{\%}, p = 0.027). Multivariate analysis revealed that prolongations of the QRS complex (118 ± 27 vs. 88 ± 10 ms, p = 0.048) and depressed left ventricular ejection fraction (41 ± 7{\%} vs. 57 ± 7{\%}, p = 0.027) were the only independent factors significantly associated with the fulminant course of acute myocarditis. Conclusion: The in-hospital mortality of acute fulminant myocarditis was high. Prolongations of the QRS complex and depressed left ventricular ejection fraction on admission were independent positive predictors for the development of acute fulminant myocarditis.",
author = "Cheng-Han Lee and Wei-Chuan Tsai and Chin-Hsin Hsu and Ping-Yen Liu and Lin, {Li Jen} and Chen, {Jyh Hong}",
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Predictive factors of a fulminant course in acute myocarditis. / Lee, Cheng-Han; Tsai, Wei-Chuan; Hsu, Chin-Hsin; Liu, Ping-Yen; Lin, Li Jen; Chen, Jyh Hong.

In: International Journal of Cardiology, Vol. 109, No. 1, 28.04.2006, p. 142-145.

Research output: Contribution to journalArticle

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T1 - Predictive factors of a fulminant course in acute myocarditis

AU - Lee, Cheng-Han

AU - Tsai, Wei-Chuan

AU - Hsu, Chin-Hsin

AU - Liu, Ping-Yen

AU - Lin, Li Jen

AU - Chen, Jyh Hong

PY - 2006/4/28

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N2 - Background: Patients who develop fulminant myocarditis often die of sudden cardiac arrest, arrhythmia, or severe heart failure soon after onset if they do not receive percutaneous cardiopulmonary support in time. The purpose of this study was to identify the risk factors of clinical symptoms/signs or laboratory findings that could predict the fulminant course of acute myocarditis. Methods and results: Thirty-five patients (mean age 28 ± 8 years, 17 males) who had been admitted to intensive care unit with the diagnosis of acute myocarditis by clinical presentations were retrospectively recruited. They were divided into the fulminant group (n = 11) and the non-fulminant group (n = 24). Clinical features, laboratory data, and images on admission were analyzed. Overall in-hospital mortality was 17% (6/35). Mortality was higher in the fulminant group (45% vs. 4%, p = 0.027). Multivariate analysis revealed that prolongations of the QRS complex (118 ± 27 vs. 88 ± 10 ms, p = 0.048) and depressed left ventricular ejection fraction (41 ± 7% vs. 57 ± 7%, p = 0.027) were the only independent factors significantly associated with the fulminant course of acute myocarditis. Conclusion: The in-hospital mortality of acute fulminant myocarditis was high. Prolongations of the QRS complex and depressed left ventricular ejection fraction on admission were independent positive predictors for the development of acute fulminant myocarditis.

AB - Background: Patients who develop fulminant myocarditis often die of sudden cardiac arrest, arrhythmia, or severe heart failure soon after onset if they do not receive percutaneous cardiopulmonary support in time. The purpose of this study was to identify the risk factors of clinical symptoms/signs or laboratory findings that could predict the fulminant course of acute myocarditis. Methods and results: Thirty-five patients (mean age 28 ± 8 years, 17 males) who had been admitted to intensive care unit with the diagnosis of acute myocarditis by clinical presentations were retrospectively recruited. They were divided into the fulminant group (n = 11) and the non-fulminant group (n = 24). Clinical features, laboratory data, and images on admission were analyzed. Overall in-hospital mortality was 17% (6/35). Mortality was higher in the fulminant group (45% vs. 4%, p = 0.027). Multivariate analysis revealed that prolongations of the QRS complex (118 ± 27 vs. 88 ± 10 ms, p = 0.048) and depressed left ventricular ejection fraction (41 ± 7% vs. 57 ± 7%, p = 0.027) were the only independent factors significantly associated with the fulminant course of acute myocarditis. Conclusion: The in-hospital mortality of acute fulminant myocarditis was high. Prolongations of the QRS complex and depressed left ventricular ejection fraction on admission were independent positive predictors for the development of acute fulminant myocarditis.

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