TY - JOUR
T1 - Prenatal assessment of normal fetal humerus volume by three-dimensional ultrasound
AU - Chang, Chiung Hsin
AU - Yu, Chen Hsiang
AU - Ko, Huei Chen
AU - Chang, Fong Ming
AU - Chen, Hsi Yao
N1 - Funding Information:
This study was supported in part by grants to F-M. Chang and to C-H. Chang from National Science Council, Taipei, Taiwan. The study was also supported in part by a grant from Premature Babies Foundation and a grant from Foundation of Behavior and Maternal-Children's Medicine. The authors are grateful to Ms. Chu-Ling Chen, Yueh-Chin Cheng and Yi-Jen Wang for their assistance.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/12
Y1 - 2003/12
N2 - Because fetal humerus dysplasia is associated with a variety of congenital syndromes, prenatal assessment of the fetal humerus growth is very important. The fetal humerus volume is one of the indexes in evaluating the humerus growth, but it has never been studied by 3-D ultrasound (US) in utero. To establish a normal reference chart of the fetal humerus volume for clinical use, we undertook a prospective and cross-sectional study using 3-D US to assess the fetal humerus volume in normal pregnancy. A total of 216 singleton fetuses that ranged between 20 and 40 weeks of gestation and fit the criteria of normal pregnancies were included in this study. Our results showed that the fetal humerus volume is highly correlated with the gestational age (GA). Using GA as the independent variable and the humerus volume as the dependent variable, the best-fit regression equation was humerus volume (mL) = 0.0044GA2 - 0.0841GA + 0.6874 (r = 0.97, n = 216, p < 0.0001). For clinical use, a chart of normal growth centiles of the fetal humerus volume was then established based on this equation. In addition, the common indexes of fetal biometry, such as biparietal diameter, occipitofrontal diameter, head circumference, abdominal circumference, femur length and estimated fetal weight, were all highly correlated with the humerus volume (all p < 0.0001). In conclusion, our data of the fetal humerus volume assessed by 3-D US can serve as a useful reference in evaluating the fetal humerus growth during normal gestation.
AB - Because fetal humerus dysplasia is associated with a variety of congenital syndromes, prenatal assessment of the fetal humerus growth is very important. The fetal humerus volume is one of the indexes in evaluating the humerus growth, but it has never been studied by 3-D ultrasound (US) in utero. To establish a normal reference chart of the fetal humerus volume for clinical use, we undertook a prospective and cross-sectional study using 3-D US to assess the fetal humerus volume in normal pregnancy. A total of 216 singleton fetuses that ranged between 20 and 40 weeks of gestation and fit the criteria of normal pregnancies were included in this study. Our results showed that the fetal humerus volume is highly correlated with the gestational age (GA). Using GA as the independent variable and the humerus volume as the dependent variable, the best-fit regression equation was humerus volume (mL) = 0.0044GA2 - 0.0841GA + 0.6874 (r = 0.97, n = 216, p < 0.0001). For clinical use, a chart of normal growth centiles of the fetal humerus volume was then established based on this equation. In addition, the common indexes of fetal biometry, such as biparietal diameter, occipitofrontal diameter, head circumference, abdominal circumference, femur length and estimated fetal weight, were all highly correlated with the humerus volume (all p < 0.0001). In conclusion, our data of the fetal humerus volume assessed by 3-D US can serve as a useful reference in evaluating the fetal humerus growth during normal gestation.
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U2 - 10.1016/j.ultrasmedbio.2003.08.012
DO - 10.1016/j.ultrasmedbio.2003.08.012
M3 - Article
C2 - 14698333
AN - SCOPUS:0346492833
SN - 0301-5629
VL - 29
SP - 1675
EP - 1680
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 12
ER -