Preparation of a series of novel bichalcones linked with a 1,4- dimethylenepiperazine moiety and examination of their cytotoxicity

Mopuru Vijaya Bhaskar Reddy, Shih Shun Chen, Meng Liang Lin, Hsiu Hui Chan, Ping Chung Kuo, Tian Shung Wu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The chalcone basic skeleton is a unique template which is associated with widespread biological activities. In the present study, a series of novel bichalcones linked with a 1,4-dimethylenepiperazine moiety was prepared through Mannich reaction and Clasien-Schmidt condensation. The synthetic analogs 2-16 were subjected into the cytotoxicity examinations using a panel of 25 human tumor cell lines. Among the tested compounds, 3 and 4 which possessed the 3-pyridyl and phenyl groups as the substructure, respectively, displayed significant cytotoxicity against all the tumor cell lines. The results suggested that these bichalcones were potential to be the anti-cancer lead drugs.

Original languageEnglish
Pages (from-to)1549-1554
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume59
Issue number12
DOIs
Publication statusPublished - 2011 Dec 12

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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