Preparation of macroporous biodegradable PLGA scaffolds for cell attachment with the use of mixed salts as porogen additives

Hong Ru Lin, Chun Jung Kuo, C. Y. Yang, Shyh Yu Shaw, Yu Jun Wu

Research output: Contribution to journalArticlepeer-review

111 Citations (Scopus)

Abstract

In the present study, a mixture of ammonium-bicarbonate (NH4HCO3) and sodium-chloride (NaCl) particles was used as a porogen additive to fabricate highly macro-porous biodegradable poly(lactic-co-glycolic acid) (PLGA)scaffolds. A two-step salt-leaching process was performed after the sample had become semisolidified. Compared to the standard solvent- casting/particulate -leaching (SC/PL) technique, the processing time of this approach was significantly shorter: Instead of several days, only half a day was required. In addition, the polymer/salts/solvent mixture can be easily handled and molded into scaffolds of any specific shape-for example, thin sheet, cylindrical, or bone-shaped-for special applications in tissue engineering. Our results demonstrate that these scaffolds have a highly interconnected open-pore structure as well as greater mechanical properties than those made using the standard SC/PL technique. Primary rat osteoblasts seeded into the scaffolds exhibited good seeding efficiency. The method presented here is a promising approach for fabricating scaffolds for tissue engineering applications.

Original languageEnglish
Pages (from-to)271-279
Number of pages9
JournalJournal of Biomedical Materials Research
Volume63
Issue number3
DOIs
Publication statusPublished - 2002 May 27

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

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