Preparation of secolycorines against acetylcholinesterase

Shoei Sheng Lee, Uppala Venkatesham, Chitneni Prasad Rao, Sio Hong Lam, Jung Hsin Lin

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

5,6-Secolycorines possessing a 5,6-dihydrophenanthridine skeleton were facilely prepared from lycorine through chemical transformations, mainly including N-alkylation, Hofmann degradation type reaction, reductive cleavage of trichloroethylcarbonyl moiety, and hydrogenation. Several secolycorine derivatives showed potent inhibitory activity against acetylcholinesterase with the IC50 value at micromolar range and are more potent than galanthamine.

Original languageEnglish
Pages (from-to)1034-1043
Number of pages10
JournalBioorganic and Medicinal Chemistry
Volume15
Issue number2
DOIs
Publication statusPublished - 2007 Jan 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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