Preparation of shell crosslinked nanoencapsulate for drug carriers by using poly(N-isopropyl acrylamide)-co-poly(L-lysine) grafted copolymer

You Liang Tu, Cheng Chien Wang, Chuh-Yung Chen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Shell crosslinked nanoencapsulate were prepared via crosslinking reaction between double hydrophilic grafted copolymers poly(N-isopropyl acrylamide)-co-poly(L-lysine) (PNIPAm-co-PLLys) and natural crosslinking agent genipin. These shell crosslinked nanoencapsulate possess spherical structures and the hydrodynamic radiuses are about 18.5 nm to 37.7 nm. Drug-loaded shell crosslinked nanoencapsulate were applied as drug carriers. Model drug methotrexate (MTX) were loaded into polymeric nanoencapsulate with different loading ratios (polymer / MTX = 10 / 0.5 and 10 / 1.0), then crosslinking agent genipin was added into micelle solution to form drug-loaded shell crosslinked nanoencapsulate. Entrapment efficiency and drug loading content of the drug-loaded shell crosslinked nanoencapsulate are about 12.66 wt% to 20.1 wt% and 0.84 wt% to 1.28 wt%, respectively. In-vitro drug release experiments of drug-loaded shell crosslinked nanoencapsulate were carried out in pH 7.4 phosphate buffer solution at 37 °C. All of these samples possess burst release in initial 8 h, and final accumulate MTX release amounts are about 71% to 97%.

Original languageEnglish
Article number134
JournalJournal of Polymer Research
Volume25
Issue number6
DOIs
Publication statusPublished - 2018 Jun 1

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Drug Carriers
Crosslinking
Lysine
Copolymers
Pharmaceutical Preparations
Methotrexate
Micelles
Phosphates
Hydrodynamics
Polymers
poly-N-isopropylacrylamide
Experiments
Buffers

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cite this

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title = "Preparation of shell crosslinked nanoencapsulate for drug carriers by using poly(N-isopropyl acrylamide)-co-poly(L-lysine) grafted copolymer",
abstract = "Shell crosslinked nanoencapsulate were prepared via crosslinking reaction between double hydrophilic grafted copolymers poly(N-isopropyl acrylamide)-co-poly(L-lysine) (PNIPAm-co-PLLys) and natural crosslinking agent genipin. These shell crosslinked nanoencapsulate possess spherical structures and the hydrodynamic radiuses are about 18.5 nm to 37.7 nm. Drug-loaded shell crosslinked nanoencapsulate were applied as drug carriers. Model drug methotrexate (MTX) were loaded into polymeric nanoencapsulate with different loading ratios (polymer / MTX = 10 / 0.5 and 10 / 1.0), then crosslinking agent genipin was added into micelle solution to form drug-loaded shell crosslinked nanoencapsulate. Entrapment efficiency and drug loading content of the drug-loaded shell crosslinked nanoencapsulate are about 12.66 wt{\%} to 20.1 wt{\%} and 0.84 wt{\%} to 1.28 wt{\%}, respectively. In-vitro drug release experiments of drug-loaded shell crosslinked nanoencapsulate were carried out in pH 7.4 phosphate buffer solution at 37 °C. All of these samples possess burst release in initial 8 h, and final accumulate MTX release amounts are about 71{\%} to 97{\%}.",
author = "Tu, {You Liang} and Wang, {Cheng Chien} and Chuh-Yung Chen",
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Preparation of shell crosslinked nanoencapsulate for drug carriers by using poly(N-isopropyl acrylamide)-co-poly(L-lysine) grafted copolymer. / Tu, You Liang; Wang, Cheng Chien; Chen, Chuh-Yung.

In: Journal of Polymer Research, Vol. 25, No. 6, 134, 01.06.2018.

Research output: Contribution to journalArticle

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AU - Wang, Cheng Chien

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PY - 2018/6/1

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AB - Shell crosslinked nanoencapsulate were prepared via crosslinking reaction between double hydrophilic grafted copolymers poly(N-isopropyl acrylamide)-co-poly(L-lysine) (PNIPAm-co-PLLys) and natural crosslinking agent genipin. These shell crosslinked nanoencapsulate possess spherical structures and the hydrodynamic radiuses are about 18.5 nm to 37.7 nm. Drug-loaded shell crosslinked nanoencapsulate were applied as drug carriers. Model drug methotrexate (MTX) were loaded into polymeric nanoencapsulate with different loading ratios (polymer / MTX = 10 / 0.5 and 10 / 1.0), then crosslinking agent genipin was added into micelle solution to form drug-loaded shell crosslinked nanoencapsulate. Entrapment efficiency and drug loading content of the drug-loaded shell crosslinked nanoencapsulate are about 12.66 wt% to 20.1 wt% and 0.84 wt% to 1.28 wt%, respectively. In-vitro drug release experiments of drug-loaded shell crosslinked nanoencapsulate were carried out in pH 7.4 phosphate buffer solution at 37 °C. All of these samples possess burst release in initial 8 h, and final accumulate MTX release amounts are about 71% to 97%.

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