Preparation of type I collagen fibrillar matrices and the effects of collagen concentration on fibroblast contraction

Lynn Ling-Huei Huang, Marcel E. Nimni

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Collagen which is predominant in the extracellular matrix, serves as a support for the connective tissues. It, and its derived matrices have been used as bioprostheses for burn wound dressings and tissues templates due to their biocompatibility. Since collagen can be present in different forms, to evaluate and standardize experimental models, collagen fibrillar matrices (CFM) were reconstituted as native type collagen fibrils from purified pepsin soluble type I collagen. The in vitro CFM contraction model developed allowed us to study the effects of the concentration of collagen on CFM contraction by fibroblasts.

Original languageEnglish
Pages (from-to)664-675
Number of pages12
JournalBiomedical Engineering - Applications, Basis and Communications
Volume5
Issue number5
Publication statusPublished - 1993 Jan 1

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomedical Engineering

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