Presence of human herpesvirus-like DNA sequence in oral Kaposi's sarcoma A preliminary PCR study

Ying Tai Jin, Sen-Tien Tsai, Jing Jou Yan, Fen Fen Chen, Wen Ying Lee, Wing Yin Li, Hung Chiang, Ih Jen Su

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

DNA sequences closely related to herpesvirus-like sequences have been found in AIDS-associated Kaposi's sarcoma. Subsequent studies indicate that these DNA sequences may be consistently found in AIDS Kaposi's sarcoma and non-AIDS Kaposi's sarcoma from different geographic regions. Oral Kaposi's sarcoma is rare and the specificity of this viral DNA in oral Kaposi's sarcoma and in other oral neoplasms has not been examined. A total of 77 oral neoplasms, including 3 Kaposi's sarcoma specimens from 2 patients with AIDS, were analyzed by polymerase chain reaction for the presence of this herpesvirus-like DNA sequence with the 330-233 primers. All three specimens of oral AIDS-Kaposi's sarcoma from two patients were positive for this DNA sequence. All of the other intraoral lesions including hemangioma, pyogenic granuloma, and various types of epithelial neoplasms, however, had negative reactions Our results further confirm that oral Kaposi's sarcoma appears to be associated with this herpesvirus-like DNA sequence.

Original languageEnglish
Pages (from-to)442-444
Number of pages3
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume81
Issue number4
DOIs
Publication statusPublished - 1996 Jan 1

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

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