Prevalence and risk factors for colonization by extended-spectrum β-lactamase-producing or ST 131 escherichia coli among asymptomatic adults in community settings in Southern Taiwan

Pin Chieh Wu, Jiun Ling Wang, Po Ren Hsueh, Po Hsiang Lin, Ming Fang Cheng, I. Fei Huang, Yao Shen Chen, Susan Shin Jung Lee, Mar Guang-Yuan, Hsien Chung Yu, Chiao Lin Hsu, Fu Wei Wang, Chi Shen Chen, Chih Hsin Hung, Wen Chien Ko

Research output: Contribution to journalArticle

Abstract

Purpose: Fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) is common in Asia, especially in China and Southeast Asia. There are no data about fecal carriage of ESBL-EC and mcr-1-positive E. coli in Taiwan, and few studies focusing on the risk factors of asymptomatic fecal carriage of epidemic ST131 E. coli have been published. Patients and methods: From healthy inhabitants attending health examinations at a medical center in southern Taiwan in 2017, we collected 724 stool samples, which were examined for ESBL-EC fecal carriage using chromogenic medium. ST131 and mcr1-positive E. coli were also investigated using multiplex PCR. Clinical data from all participating adults were collected to analyze the risk factors for fecal ESBL-EC or ST131 E. coli carriage. Results: The prevalence rate of asymptomatic ESBL-EC fecal carriage in adults was 1.9% (14/724). ST131 was found in 22 (3.0%) adults and mcr-1-positive E. coli was found in three (0.4%) adults. A multivariate analysis showed that the risk factors associated with ESBL-EC carriage were diabetes mellitus (adjusted odds ratio [aOR]: 5.5, 95% confidence interval [CI]: 1.3–22.7), a history of colonic polyps (aOR: 6.4, 95% CI: 1.6–24.9), and chronic renal insufficiency (aOR: 20.7, 95% CI: 1.4–305.7). Underlying cancer (aOR: 4.8, 95% CI: 1.0–22.5) and stroke (aOR: 18.0, 95% CI: 1.6–207.5) were associated with ST131 E. coli fecal carriage. In our cohort, travel to Asian countries and food habit were not associated with ST131 or ESBL-EC fecal carriage. Conclusions: The ESBL-EC or ST131 E. coli fecal carriage rate is low among asymptomatic adults in Taiwan. Certain underlying medical conditions were associated with their fecal carriage.

Original languageEnglish
Pages (from-to)1063-1071
Number of pages9
JournalInfection and Drug Resistance
Volume12
DOIs
Publication statusPublished - 2019 Jan 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Infectious Diseases
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Prevalence and risk factors for colonization by extended-spectrum β-lactamase-producing or ST 131 escherichia coli among asymptomatic adults in community settings in Southern Taiwan'. Together they form a unique fingerprint.

  • Cite this

    Wu, P. C., Wang, J. L., Hsueh, P. R., Lin, P. H., Cheng, M. F., Huang, I. F., Chen, Y. S., Lee, S. S. J., Guang-Yuan, M., Yu, H. C., Hsu, C. L., Wang, F. W., Chen, C. S., Hung, C. H., & Ko, W. C. (2019). Prevalence and risk factors for colonization by extended-spectrum β-lactamase-producing or ST 131 escherichia coli among asymptomatic adults in community settings in Southern Taiwan. Infection and Drug Resistance, 12, 1063-1071. https://doi.org/10.2147/IDR.S201086