Prevalence, implication, and viral nucleotide sequence analysis of GB virus-C/hepatitis G virus infection in acute fulminant and nonfulminant hepatitis

Jaw Ching Wu, Tzen-Yuh Chiang, Yi Hsiang Huang, Teh Ia Huo, Shing Jang Hwang, I. Shinn Huang, Wen Yung Sheng, Shou Dong Lee

Research output: Contribution to journalArticle

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Abstract

The clinical impact of GB virus-C (GBV-C)/hepatitis G virus (HGV) infection on various causes of acute hepatitis and fulminant hepatitis is controversial. In this study, serum samples from 164 patients with acute hepatitis of various causes, 34 asymptomatic hepatitis B virus (HBV) carriers, and 34 healthy adults were tested for GBV-C/HGV RNA by reverse transcription-nested polymerase chain reaction using primers based on the 5'- untranslated region. Nucleotide sequences of GBV-C/HGV RNA from various groups were compared. The prevalence of GBV-C/HGV RNA was significantly higher in patients with acute hepatitis D virus (HDV) superinfection than in HBV carriers or healthy controls (10/37 vs. 2/34, P< 0.02; 10/37 vs. 1/34, P< 0.005). GBV-C/HGV RNA was detected in 11.1% of acute hepatitis A patients, 9.5% of acute hepatitis B patients, 15.8% of acute hepatitis C patients, 12.5% of acute hepatitis E patients, 11.8% of chronic hepatitis B patients with acute exacerbation, and 11.1% in patients with non-A to -E hepatitis; each was not significantly higher than that in HBV carriers or healthy adults. There were no significant differences in gender, age, serum albumin, bilirubin, and alanine aminotransferase levels nor in the occurrence of fulminant hepatitis (6/28 vs. 36/136) between patients with or without GBV- C/HGV RNA. All six patients with fulminant hepatitis who had GBV-C/HGV RNA were complicated by infection with hepatitis B, C, or D. The GBV-C/HGV clones from 21 patients with or without fulminant hepatitis belonged to group 3. No particular strain of GBV-C/HGV was associated with fulminant hepatitis.

Original languageEnglish
Pages (from-to)118-122
Number of pages5
JournalJournal of Medical Virology
Volume56
Issue number2
DOIs
Publication statusPublished - 1998 Oct 1

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GB virus C
Virus Diseases
Hepatitis
Sequence Analysis
RNA
Hepatitis B virus
Hepatitis E
Hepatitis C
Hepatitis B
Hepatitis D
Hepatitis Delta Virus

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Wu, Jaw Ching ; Chiang, Tzen-Yuh ; Huang, Yi Hsiang ; Huo, Teh Ia ; Hwang, Shing Jang ; Huang, I. Shinn ; Sheng, Wen Yung ; Lee, Shou Dong. / Prevalence, implication, and viral nucleotide sequence analysis of GB virus-C/hepatitis G virus infection in acute fulminant and nonfulminant hepatitis. In: Journal of Medical Virology. 1998 ; Vol. 56, No. 2. pp. 118-122.
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abstract = "The clinical impact of GB virus-C (GBV-C)/hepatitis G virus (HGV) infection on various causes of acute hepatitis and fulminant hepatitis is controversial. In this study, serum samples from 164 patients with acute hepatitis of various causes, 34 asymptomatic hepatitis B virus (HBV) carriers, and 34 healthy adults were tested for GBV-C/HGV RNA by reverse transcription-nested polymerase chain reaction using primers based on the 5'- untranslated region. Nucleotide sequences of GBV-C/HGV RNA from various groups were compared. The prevalence of GBV-C/HGV RNA was significantly higher in patients with acute hepatitis D virus (HDV) superinfection than in HBV carriers or healthy controls (10/37 vs. 2/34, P< 0.02; 10/37 vs. 1/34, P< 0.005). GBV-C/HGV RNA was detected in 11.1{\%} of acute hepatitis A patients, 9.5{\%} of acute hepatitis B patients, 15.8{\%} of acute hepatitis C patients, 12.5{\%} of acute hepatitis E patients, 11.8{\%} of chronic hepatitis B patients with acute exacerbation, and 11.1{\%} in patients with non-A to -E hepatitis; each was not significantly higher than that in HBV carriers or healthy adults. There were no significant differences in gender, age, serum albumin, bilirubin, and alanine aminotransferase levels nor in the occurrence of fulminant hepatitis (6/28 vs. 36/136) between patients with or without GBV- C/HGV RNA. All six patients with fulminant hepatitis who had GBV-C/HGV RNA were complicated by infection with hepatitis B, C, or D. The GBV-C/HGV clones from 21 patients with or without fulminant hepatitis belonged to group 3. No particular strain of GBV-C/HGV was associated with fulminant hepatitis.",
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Prevalence, implication, and viral nucleotide sequence analysis of GB virus-C/hepatitis G virus infection in acute fulminant and nonfulminant hepatitis. / Wu, Jaw Ching; Chiang, Tzen-Yuh; Huang, Yi Hsiang; Huo, Teh Ia; Hwang, Shing Jang; Huang, I. Shinn; Sheng, Wen Yung; Lee, Shou Dong.

In: Journal of Medical Virology, Vol. 56, No. 2, 01.10.1998, p. 118-122.

Research output: Contribution to journalArticle

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AU - Wu, Jaw Ching

AU - Chiang, Tzen-Yuh

AU - Huang, Yi Hsiang

AU - Huo, Teh Ia

AU - Hwang, Shing Jang

AU - Huang, I. Shinn

AU - Sheng, Wen Yung

AU - Lee, Shou Dong

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N2 - The clinical impact of GB virus-C (GBV-C)/hepatitis G virus (HGV) infection on various causes of acute hepatitis and fulminant hepatitis is controversial. In this study, serum samples from 164 patients with acute hepatitis of various causes, 34 asymptomatic hepatitis B virus (HBV) carriers, and 34 healthy adults were tested for GBV-C/HGV RNA by reverse transcription-nested polymerase chain reaction using primers based on the 5'- untranslated region. Nucleotide sequences of GBV-C/HGV RNA from various groups were compared. The prevalence of GBV-C/HGV RNA was significantly higher in patients with acute hepatitis D virus (HDV) superinfection than in HBV carriers or healthy controls (10/37 vs. 2/34, P< 0.02; 10/37 vs. 1/34, P< 0.005). GBV-C/HGV RNA was detected in 11.1% of acute hepatitis A patients, 9.5% of acute hepatitis B patients, 15.8% of acute hepatitis C patients, 12.5% of acute hepatitis E patients, 11.8% of chronic hepatitis B patients with acute exacerbation, and 11.1% in patients with non-A to -E hepatitis; each was not significantly higher than that in HBV carriers or healthy adults. There were no significant differences in gender, age, serum albumin, bilirubin, and alanine aminotransferase levels nor in the occurrence of fulminant hepatitis (6/28 vs. 36/136) between patients with or without GBV- C/HGV RNA. All six patients with fulminant hepatitis who had GBV-C/HGV RNA were complicated by infection with hepatitis B, C, or D. The GBV-C/HGV clones from 21 patients with or without fulminant hepatitis belonged to group 3. No particular strain of GBV-C/HGV was associated with fulminant hepatitis.

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