TY - JOUR
T1 - Primary biliary cirrhosis with negative anti-mitochondrial antibody
T2 - A case report
AU - Tsai, Yuan Ming
AU - Chou, Nan Hwa
AU - Cheng, Pin Nan
AU - Chang, Ting Tsung
PY - 2003/10/1
Y1 - 2003/10/1
N2 - Primary biliary cirrhosis (PBC) is characterized by fatigue, pruritus, or hepatomegaly, and by the presence of anti-mitochondrial antibody (AMA). We report on a 55-year-old female with PBC, but who was negative for AMA. She had elevated liver biochemistry, especially alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT), which in the indicate cholestasis. Abdominal sonography revealed liver cirrhosis with no evidence of biliary tract dilatation. Liver pathology showed loss of the bile duct, lymphocyte infiltration within portal areas, and granuloma formation. The diagnosis of PBC was confirmed by pathologic findings in addition to immunoglbulin (Ig) M and antinuclear antibody (ANA). She received oral ursodeoxycholic acid at a dosage of 12 mg/kg/ day. After 10 years of treatment, liver function has been well controlled, and she has nearly normal liver biochemical tests.
AB - Primary biliary cirrhosis (PBC) is characterized by fatigue, pruritus, or hepatomegaly, and by the presence of anti-mitochondrial antibody (AMA). We report on a 55-year-old female with PBC, but who was negative for AMA. She had elevated liver biochemistry, especially alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT), which in the indicate cholestasis. Abdominal sonography revealed liver cirrhosis with no evidence of biliary tract dilatation. Liver pathology showed loss of the bile duct, lymphocyte infiltration within portal areas, and granuloma formation. The diagnosis of PBC was confirmed by pathologic findings in addition to immunoglbulin (Ig) M and antinuclear antibody (ANA). She received oral ursodeoxycholic acid at a dosage of 12 mg/kg/ day. After 10 years of treatment, liver function has been well controlled, and she has nearly normal liver biochemical tests.
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M3 - Article
AN - SCOPUS:0141592544
SN - 1016-3190
VL - 15
SP - 347
EP - 351
JO - Tzu Chi Medical Journal
JF - Tzu Chi Medical Journal
IS - 5
ER -