Primary biliary cirrhosis with negative anti-mitochondrial antibody: A case report

Yuan Ming Tsai, Nan Hwa Chou, Pin Nan Cheng, Ting Tsung Chang

Research output: Contribution to journalArticlepeer-review


Primary biliary cirrhosis (PBC) is characterized by fatigue, pruritus, or hepatomegaly, and by the presence of anti-mitochondrial antibody (AMA). We report on a 55-year-old female with PBC, but who was negative for AMA. She had elevated liver biochemistry, especially alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT), which in the indicate cholestasis. Abdominal sonography revealed liver cirrhosis with no evidence of biliary tract dilatation. Liver pathology showed loss of the bile duct, lymphocyte infiltration within portal areas, and granuloma formation. The diagnosis of PBC was confirmed by pathologic findings in addition to immunoglbulin (Ig) M and antinuclear antibody (ANA). She received oral ursodeoxycholic acid at a dosage of 12 mg/kg/ day. After 10 years of treatment, liver function has been well controlled, and she has nearly normal liver biochemical tests.

Original languageEnglish
Pages (from-to)347-351
Number of pages5
JournalTzu Chi Medical Journal
Issue number5
Publication statusPublished - 2003 Oct 1

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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