Primary vaginal amelanotic melanoma

Hsia Kuei Huang, I. Feng Liu, Chung-Liang Ho, Cheng-Yang Chou, Ya-Min Cheng

Research output: Contribution to journalArticle

Abstract

Objective: Primary vaginal melanoma is a very rare tumor entity, with a poor prognosis. The diagnosis is evident when melanin pigment is present within the tumor. However, the diagnosis of an amelanotic melanoma is problematic and should be differentiated from other conditions such as sarcoma, adenocarcinoma or small cell carcinoma. We present a patient with abnormal vaginal bleeding, with a diagnosis of amelanotic melanoma of the vagina confirmed by immunohistopathologic examination. Case Report: A 78-year-old woman was brought to our hospital because of postmenopausal vaginal bleeding for several days. Physical examination revealed two erythematous nodules, about 1 cm in size, in the upper-third of the vagina. Biopsy of the vaginal tumor showed a high-grade sarcoma. She underwent a wide local excision of the lesion, and histology confirmed the diagnosis of amelanotic melanoma due to strong staining of Melan-A. Conclusion: The diagnosis of amelanotic melanoma of the vagina is sometimes difficult. Immunohistochemistry may be required to provide additional diagnostic information in problematic cases.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
JournalTaiwanese Journal of Obstetrics and Gynecology
Volume44
Issue number2
DOIs
Publication statusPublished - 2005 Jan 1

Fingerprint

Amelanotic Melanoma
Vagina
Uterine Hemorrhage
Sarcoma
MART-1 Antigen
Neoplasms
Small Cell Carcinoma
Melanins
Physical Examination
Melanoma
Histology
Adenocarcinoma
Immunohistochemistry
Staining and Labeling
Biopsy

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

@article{304d48655dbb4f71afba70b2bfaae6a5,
title = "Primary vaginal amelanotic melanoma",
abstract = "Objective: Primary vaginal melanoma is a very rare tumor entity, with a poor prognosis. The diagnosis is evident when melanin pigment is present within the tumor. However, the diagnosis of an amelanotic melanoma is problematic and should be differentiated from other conditions such as sarcoma, adenocarcinoma or small cell carcinoma. We present a patient with abnormal vaginal bleeding, with a diagnosis of amelanotic melanoma of the vagina confirmed by immunohistopathologic examination. Case Report: A 78-year-old woman was brought to our hospital because of postmenopausal vaginal bleeding for several days. Physical examination revealed two erythematous nodules, about 1 cm in size, in the upper-third of the vagina. Biopsy of the vaginal tumor showed a high-grade sarcoma. She underwent a wide local excision of the lesion, and histology confirmed the diagnosis of amelanotic melanoma due to strong staining of Melan-A. Conclusion: The diagnosis of amelanotic melanoma of the vagina is sometimes difficult. Immunohistochemistry may be required to provide additional diagnostic information in problematic cases.",
author = "Huang, {Hsia Kuei} and Liu, {I. Feng} and Chung-Liang Ho and Cheng-Yang Chou and Ya-Min Cheng",
year = "2005",
month = "1",
day = "1",
doi = "10.1016/S1028-4559(09)60135-2",
language = "English",
volume = "44",
pages = "177--179",
journal = "Taiwanese Journal of Obstetrics and Gynecology",
issn = "1028-4559",
publisher = "Elsevier Taiwan LLC",
number = "2",

}

Primary vaginal amelanotic melanoma. / Huang, Hsia Kuei; Liu, I. Feng; Ho, Chung-Liang; Chou, Cheng-Yang; Cheng, Ya-Min.

In: Taiwanese Journal of Obstetrics and Gynecology, Vol. 44, No. 2, 01.01.2005, p. 177-179.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Primary vaginal amelanotic melanoma

AU - Huang, Hsia Kuei

AU - Liu, I. Feng

AU - Ho, Chung-Liang

AU - Chou, Cheng-Yang

AU - Cheng, Ya-Min

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Objective: Primary vaginal melanoma is a very rare tumor entity, with a poor prognosis. The diagnosis is evident when melanin pigment is present within the tumor. However, the diagnosis of an amelanotic melanoma is problematic and should be differentiated from other conditions such as sarcoma, adenocarcinoma or small cell carcinoma. We present a patient with abnormal vaginal bleeding, with a diagnosis of amelanotic melanoma of the vagina confirmed by immunohistopathologic examination. Case Report: A 78-year-old woman was brought to our hospital because of postmenopausal vaginal bleeding for several days. Physical examination revealed two erythematous nodules, about 1 cm in size, in the upper-third of the vagina. Biopsy of the vaginal tumor showed a high-grade sarcoma. She underwent a wide local excision of the lesion, and histology confirmed the diagnosis of amelanotic melanoma due to strong staining of Melan-A. Conclusion: The diagnosis of amelanotic melanoma of the vagina is sometimes difficult. Immunohistochemistry may be required to provide additional diagnostic information in problematic cases.

AB - Objective: Primary vaginal melanoma is a very rare tumor entity, with a poor prognosis. The diagnosis is evident when melanin pigment is present within the tumor. However, the diagnosis of an amelanotic melanoma is problematic and should be differentiated from other conditions such as sarcoma, adenocarcinoma or small cell carcinoma. We present a patient with abnormal vaginal bleeding, with a diagnosis of amelanotic melanoma of the vagina confirmed by immunohistopathologic examination. Case Report: A 78-year-old woman was brought to our hospital because of postmenopausal vaginal bleeding for several days. Physical examination revealed two erythematous nodules, about 1 cm in size, in the upper-third of the vagina. Biopsy of the vaginal tumor showed a high-grade sarcoma. She underwent a wide local excision of the lesion, and histology confirmed the diagnosis of amelanotic melanoma due to strong staining of Melan-A. Conclusion: The diagnosis of amelanotic melanoma of the vagina is sometimes difficult. Immunohistochemistry may be required to provide additional diagnostic information in problematic cases.

UR - http://www.scopus.com/inward/record.url?scp=22144476878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22144476878&partnerID=8YFLogxK

U2 - 10.1016/S1028-4559(09)60135-2

DO - 10.1016/S1028-4559(09)60135-2

M3 - Article

AN - SCOPUS:22144476878

VL - 44

SP - 177

EP - 179

JO - Taiwanese Journal of Obstetrics and Gynecology

JF - Taiwanese Journal of Obstetrics and Gynecology

SN - 1028-4559

IS - 2

ER -