Probing the association between dexamethasone-induced cortisol suppression and serotonin transporter availability among drug-free patients with major depressive disorder-A small-sample SPECT study with [123I]ADAM

Hsin Chun Tsai, Shih Hsien Lin, I. Hui Lee, Po See Chen, Kao Chin Chen, Tzung Lieh Yeh, Wei Jen Yao, Nan Tsing Chiu, Ru Band Lu, Yen Kuang Yang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The association between hypothalamo-pituitary-adrenal (HPA) axis function and the serotonergic system could be involved in the mechanism of depression. However, neuroimaging evidence is scarce. The aim of the present study was to probe the association between dexamethasone suppression test response and serotonin transporter (SERT) availability in drug-free patients with major depressive disorder (MDD). Seventeen MDD patients (five males and twelve females) were recruited. SPECT with [123I] ADAM was used to measure the midbrain SERT availability, and HPA axis function was measured by the dexamethasone suppression test (DST). The association was significant when considering all participants (ρ=0.69, p=0.002). This association may have clinical implications for the treatment of MDD.

Original languageEnglish
Pages (from-to)2805-2809
Number of pages5
JournalPsychoneuroendocrinology
Volume38
Issue number11
DOIs
Publication statusPublished - 2013 Nov 1

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry

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