Production and Recovery of Ectoine: A Review of Current State and Future Prospects

Hui Suan Ng, Pik Ki Wan, Akihiko Kondo, Jo Shu Chang, John Chi Wei Lan

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a revolutionizing substance with vast applications in the cosmetic and food industries. Ectoine is often sourced from halobacteria. The increasing market demand for ectoine has urged the development of cost-effective and sustainable large-scale production of ectoine from microbial sources. This review describes the existing and potential microbial sources of ectoine and its derivatives, as well as microbial production and fermentation approaches for ectoine recovery. In addition, conventional methods and emerging technologies for enhanced production and recovery of ectoine from microbial fermentation with a focus on the aqueous biphasic system (ABS) are discussed. The ABS is a practically feasible approach for the integration of fermentation, cell disruption, bioconversion, and clarification of various biomolecules in a single-step operation. Nonetheless, the implementation of the ABS on an industrial-scale basis for the enhanced production and recovery of ectoine is yet to be exploited. Therefore, the feasibility of the ABS to integrate the production and direct recovery of ectoine from microbial sources is also highlighted in this review.

Original languageEnglish
Article number339
Issue number2
Publication statusPublished - 2023 Feb

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Process Chemistry and Technology


Dive into the research topics of 'Production and Recovery of Ectoine: A Review of Current State and Future Prospects'. Together they form a unique fingerprint.

Cite this