Production of monodisperse micron-size droplets using silicon-based MHzultrasonic nozzles for biomedical applications

Shirley C. Tsai, Yu L. Song, Chih H. Cheng, Yuan F. Chou, Chin T. Lee, Ning Wang, Rong W. Mao, Chen S. Tsai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports production of 4.5 μm-diameter monodisperse water droplets using silicon-based one MHz ultrasonic nozzles of a novel design. The novel design of multiple Fourier horns in resonance facilitates pure capillary mechanism atomization. The measured drop diameters in very good agreement with those predicted by the capillary wave atomization mechanism. Due to the resonance effect, the power and voltage requirements for atomization were as low as 15 mW and 6.5 V at atomization rate as high as 300 μ1/min. The droplet diameter was reduced to 4.1 μm when surface tension of the liquid was reduced from 70 dyne/cm (water) to 50 dyne/cm (0.25% Triton X-100 surfactant solution). Such small as diameter drops with GSD (geometrical standard deviation) as small as 1.1 was achieved in ultrasonic atomization for the first time. Note that the fraction of all particles smaller than 5.8 μm in diameter represents the inhaleable fine particle fraction and GSD of 1.3 or smaller is commonly accepted as the standard for monodispersity. Therefore, the MEMS-based MHz ultrasonic nozzle should have very significant impacts on targeted delivery of reproducible doses of medicine to the respiratory system.

Original languageEnglish
Title of host publication2008 Proceedings of the 3rd Frontiers in Biomedical Devices Conference and Exhibition
Pages27-28
Number of pages2
Publication statusPublished - 2008 Dec 1
Event2008 3rd Frontiers in Biomedical Devices Conference and Exhibition - Irvine, CA, United States
Duration: 2008 Jun 182008 Jun 20

Publication series

Name2008 Proceedings of the 3rd Frontiers in Biomedical Devices Conference and Exhibition

Other

Other2008 3rd Frontiers in Biomedical Devices Conference and Exhibition
CountryUnited States
CityIrvine, CA
Period08-06-1808-06-20

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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