Abstract
Background: Haphazard cell proliferation is a fundamental biologic defect in cancer. Thus, assessment of the growth fraction provides a valuable index of biological property for human neoplasm. Proliferating cell nuclear antigen (PCNA) expression has been used to estimate the growth fraction of human cancer, and its prognostic value. Information in transitional cell carcinoma (TCC) of the upper urinary tract, however, is very few. Materials and Methods: A total of 73 patients with TCC of the upper urinary tract was collected between July 1988 and December 1995 for this study. The labeling index of PCNA immunostaining was correlated with clinicopathologic factors and compared for its prognostic value with a median follow-up of 54 months. Results: The PCNA index was positively associated with histological grading, tumor stage and patient prognosis (P = 0.00, respectively). Multivariate analysis demonstrated that significant factors in relation to patient survival were tumor stage (P = 0.01), followed by PCNA index (P = 0.04) and gender of patients (P = 0.04). Multiple comparison revealed that PCNA index set at 0.30 had prognostic value in terms of patient survival (P = 0.00), and the risk of metachronous bladder recurrence (P = 0.02). Conclusion: Our data suggested that assessment of PCNA index may be used as an adjuvant prognostic factor for patients with TCC of the upper urinary tract.
| Original language | English |
|---|---|
| Pages (from-to) | 2789-2793 |
| Number of pages | 5 |
| Journal | Anticancer Research |
| Volume | 17 |
| Issue number | 4 A |
| Publication status | Published - 1997 Sep 3 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
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Prognostic significance of proliferating cell nuclear antigen expression in transitional cell carcinoma of the upper urinary tract. / Cheng, Hong-Lin; Chow, Nan-Haw; Tzai, Tzong Shin; Tong, Yat-Ching; Lin, Johnny Shinn Nan; Chan, Shih-Huang; Yang, Wen-Horng; Chang, Chien Chen; Lin, YungMing.
In: Anticancer Research, Vol. 17, No. 4 A, 03.09.1997, p. 2789-2793.Research output: Contribution to journal › Article
TY - JOUR
T1 - Prognostic significance of proliferating cell nuclear antigen expression in transitional cell carcinoma of the upper urinary tract
AU - Cheng, Hong-Lin
AU - Chow, Nan-Haw
AU - Tzai, Tzong Shin
AU - Tong, Yat-Ching
AU - Lin, Johnny Shinn Nan
AU - Chan, Shih-Huang
AU - Yang, Wen-Horng
AU - Chang, Chien Chen
AU - Lin, YungMing
PY - 1997/9/3
Y1 - 1997/9/3
N2 - Background: Haphazard cell proliferation is a fundamental biologic defect in cancer. Thus, assessment of the growth fraction provides a valuable index of biological property for human neoplasm. Proliferating cell nuclear antigen (PCNA) expression has been used to estimate the growth fraction of human cancer, and its prognostic value. Information in transitional cell carcinoma (TCC) of the upper urinary tract, however, is very few. Materials and Methods: A total of 73 patients with TCC of the upper urinary tract was collected between July 1988 and December 1995 for this study. The labeling index of PCNA immunostaining was correlated with clinicopathologic factors and compared for its prognostic value with a median follow-up of 54 months. Results: The PCNA index was positively associated with histological grading, tumor stage and patient prognosis (P = 0.00, respectively). Multivariate analysis demonstrated that significant factors in relation to patient survival were tumor stage (P = 0.01), followed by PCNA index (P = 0.04) and gender of patients (P = 0.04). Multiple comparison revealed that PCNA index set at 0.30 had prognostic value in terms of patient survival (P = 0.00), and the risk of metachronous bladder recurrence (P = 0.02). Conclusion: Our data suggested that assessment of PCNA index may be used as an adjuvant prognostic factor for patients with TCC of the upper urinary tract.
AB - Background: Haphazard cell proliferation is a fundamental biologic defect in cancer. Thus, assessment of the growth fraction provides a valuable index of biological property for human neoplasm. Proliferating cell nuclear antigen (PCNA) expression has been used to estimate the growth fraction of human cancer, and its prognostic value. Information in transitional cell carcinoma (TCC) of the upper urinary tract, however, is very few. Materials and Methods: A total of 73 patients with TCC of the upper urinary tract was collected between July 1988 and December 1995 for this study. The labeling index of PCNA immunostaining was correlated with clinicopathologic factors and compared for its prognostic value with a median follow-up of 54 months. Results: The PCNA index was positively associated with histological grading, tumor stage and patient prognosis (P = 0.00, respectively). Multivariate analysis demonstrated that significant factors in relation to patient survival were tumor stage (P = 0.01), followed by PCNA index (P = 0.04) and gender of patients (P = 0.04). Multiple comparison revealed that PCNA index set at 0.30 had prognostic value in terms of patient survival (P = 0.00), and the risk of metachronous bladder recurrence (P = 0.02). Conclusion: Our data suggested that assessment of PCNA index may be used as an adjuvant prognostic factor for patients with TCC of the upper urinary tract.
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M3 - Article
C2 - 9252716
AN - SCOPUS:0030755651
VL - 17
SP - 2789
EP - 2793
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 4 A
ER -