Prognostic value and the changes of plasma levels of secretory type II phospholipase A2 in patients with coronary artery disease undergoing percutaneous coronary intervention

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Abstract

Aim: To evaluate the serial changes of plasma secretory type II phospholipase A2 (sPLA2), C-reactive protein (CRP) and cardiac injury markers in coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI) and their prognostic impacts. Methods and results: Plasma levels of sPLA2, CRP, creatine kinase (CK), CK-MB and troponin-T were measured in 247 consecutive CAD patients receiving PCI procedure and 100 control subjects without CAD. In CAD group, serial blood samples were taken before coronary angiography, after coronary angiography, immediately after PCI, 24-h and 48-h after PCI. The sPLA2 and CRP levels did not change after coronary angiography. The level of sPLA2 significantly increased immediately after PCI. Creatine kinase and cardiac injury markers did not rise immediately after PCI, but elevated significantly at 24 h after intervention. After a 2-year follow up, increased sPLA 2 (>450 ng/dl) after PCI, smoking and diabetes mellitus were the independent risk factors for subsequent coronary events (odds ratios 2.1, 2.3 and 3.1, respectively) in patients with CAD. Conclusion: The present study showed that PCI might cause immediate elevation of circulating levels of sPLA2 following the mechanical disruption of coronary plaque, and the elevated level of sPLA2 had significant prognostic impact.

Original languageEnglish
Pages (from-to)1824-1832
Number of pages9
JournalEuropean Heart Journal
Volume24
Issue number20
DOIs
Publication statusPublished - 2003 Oct 1

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Secretory Phospholipase A2
Percutaneous Coronary Intervention
Coronary Artery Disease
Type C Phospholipases
Coronary Angiography
C-Reactive Protein
Creatine Kinase
MB Form Creatine Kinase
Troponin T
Wounds and Injuries
Protein Kinases
Diabetes Mellitus
Smoking
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Prognostic value and the changes of plasma levels of secretory type II phospholipase A2 in patients with coronary artery disease undergoing percutaneous coronary intervention",
abstract = "Aim: To evaluate the serial changes of plasma secretory type II phospholipase A2 (sPLA2), C-reactive protein (CRP) and cardiac injury markers in coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI) and their prognostic impacts. Methods and results: Plasma levels of sPLA2, CRP, creatine kinase (CK), CK-MB and troponin-T were measured in 247 consecutive CAD patients receiving PCI procedure and 100 control subjects without CAD. In CAD group, serial blood samples were taken before coronary angiography, after coronary angiography, immediately after PCI, 24-h and 48-h after PCI. The sPLA2 and CRP levels did not change after coronary angiography. The level of sPLA2 significantly increased immediately after PCI. Creatine kinase and cardiac injury markers did not rise immediately after PCI, but elevated significantly at 24 h after intervention. After a 2-year follow up, increased sPLA 2 (>450 ng/dl) after PCI, smoking and diabetes mellitus were the independent risk factors for subsequent coronary events (odds ratios 2.1, 2.3 and 3.1, respectively) in patients with CAD. Conclusion: The present study showed that PCI might cause immediate elevation of circulating levels of sPLA2 following the mechanical disruption of coronary plaque, and the elevated level of sPLA2 had significant prognostic impact.",
author = "Liu, {Ping Yen} and Li, {Yi Heng} and Tsai, {Wei Chuan} and Chao, {Ting Hsing} and Tsai, {Liang Miin} and Wu, {Hua Lin} and Chen, {Jyh Hong}",
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T1 - Prognostic value and the changes of plasma levels of secretory type II phospholipase A2 in patients with coronary artery disease undergoing percutaneous coronary intervention

AU - Liu, Ping Yen

AU - Li, Yi Heng

AU - Tsai, Wei Chuan

AU - Chao, Ting Hsing

AU - Tsai, Liang Miin

AU - Wu, Hua Lin

AU - Chen, Jyh Hong

PY - 2003/10/1

Y1 - 2003/10/1

N2 - Aim: To evaluate the serial changes of plasma secretory type II phospholipase A2 (sPLA2), C-reactive protein (CRP) and cardiac injury markers in coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI) and their prognostic impacts. Methods and results: Plasma levels of sPLA2, CRP, creatine kinase (CK), CK-MB and troponin-T were measured in 247 consecutive CAD patients receiving PCI procedure and 100 control subjects without CAD. In CAD group, serial blood samples were taken before coronary angiography, after coronary angiography, immediately after PCI, 24-h and 48-h after PCI. The sPLA2 and CRP levels did not change after coronary angiography. The level of sPLA2 significantly increased immediately after PCI. Creatine kinase and cardiac injury markers did not rise immediately after PCI, but elevated significantly at 24 h after intervention. After a 2-year follow up, increased sPLA 2 (>450 ng/dl) after PCI, smoking and diabetes mellitus were the independent risk factors for subsequent coronary events (odds ratios 2.1, 2.3 and 3.1, respectively) in patients with CAD. Conclusion: The present study showed that PCI might cause immediate elevation of circulating levels of sPLA2 following the mechanical disruption of coronary plaque, and the elevated level of sPLA2 had significant prognostic impact.

AB - Aim: To evaluate the serial changes of plasma secretory type II phospholipase A2 (sPLA2), C-reactive protein (CRP) and cardiac injury markers in coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI) and their prognostic impacts. Methods and results: Plasma levels of sPLA2, CRP, creatine kinase (CK), CK-MB and troponin-T were measured in 247 consecutive CAD patients receiving PCI procedure and 100 control subjects without CAD. In CAD group, serial blood samples were taken before coronary angiography, after coronary angiography, immediately after PCI, 24-h and 48-h after PCI. The sPLA2 and CRP levels did not change after coronary angiography. The level of sPLA2 significantly increased immediately after PCI. Creatine kinase and cardiac injury markers did not rise immediately after PCI, but elevated significantly at 24 h after intervention. After a 2-year follow up, increased sPLA 2 (>450 ng/dl) after PCI, smoking and diabetes mellitus were the independent risk factors for subsequent coronary events (odds ratios 2.1, 2.3 and 3.1, respectively) in patients with CAD. Conclusion: The present study showed that PCI might cause immediate elevation of circulating levels of sPLA2 following the mechanical disruption of coronary plaque, and the elevated level of sPLA2 had significant prognostic impact.

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