Prolactin response to single and multiple doses of haloperidol in schizophrenic patients

G. K. Ravichandran, Ru Band Lu, Alla Shvartsburd, Chandra H. Misra, Beng T. Ho, Myrna Kahn, Robert C. Smith

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10 Citations (Scopus)

Abstract

Serum prolactin and blood levels of haloperidol were assessed in schizophrenic patients after single acute oral doses of haloperidol and during fixed dose treatment with this medication. Although significant intrapatient correlations between prolactin responses to different doses of haloperidol were found, no statistically significant interpatient relationship between haloperidol dose and prolactin response emerged. There were statistically significant relationships between steady-state plasma and red cell haloperidol levels (measured by radio- receptor or gas liquid chromatographic techniques) and serum prolactin response, but not between blood levels after the acute haloperidol dose and prolactin response.

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalPsychiatry Research
Volume11
Issue number1
DOIs
Publication statusPublished - 1984 Jan

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Ravichandran, G. K., Lu, R. B., Shvartsburd, A., Misra, C. H., Ho, B. T., Kahn, M., & Smith, R. C. (1984). Prolactin response to single and multiple doses of haloperidol in schizophrenic patients. Psychiatry Research, 11(1), 61-69. https://doi.org/10.1016/0165-1781(84)90108-2