Proliferative and protective effects of SurR9-C84A on differentiated neural cells

Sara Baratchi, Rupinder K. Kanwar, Chun Hei Antonio Cheung, Jagat R. Kanwar

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Targeting survivin has the ability to inhibit apoptosis and regulate mitosis for the protection of neuronal cells, and it offers several advantages for neuronal repair and protection. We found that the BIR motif mutant of survivin (SurR9-C84A) can bind to microtubules and regulate their stability, induce cell division, increase proliferation and activate the expression of cell cycle and neuronal markers in differentiated SK-N-SH and HCN-2 neurons. We further showed the protective effects of SurR9-C84A against post differentiation retinoic acid induced neurotoxicity. These abilities of SurR9-C84A offer a great potential for future neuronal repair therapy.

Original languageEnglish
Pages (from-to)120-132
Number of pages13
JournalJournal of Neuroimmunology
Volume227
Issue number1-2
DOIs
Publication statusPublished - 2010 Oct 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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