Prolong antibiotics release by encapsulating PLGA for hip prosthesis

K. H. Chen, G. A. Lai, S. D. Chen, J. C. Shiu, Ming-Long Yeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, encapsulating antibiotic loaded titanium alloy by polylactide-co-polyglycoJide copolymer (PLGA) for preventing burst releasing and extending antibiotic releasing time will be make for potential future hip prosthesis with deep infection prevention ability. Antibiotics, vancomycin and cefuroxime, were used to measure their temporal release from titanium disc. The result by elution test showed non PLGA coated of antibiotic loaded groups was released at the first hour. For PLGA (85/15) coated groups, vancomycin could still be detected after 5 days, and cefuroxime groups extended the releasing period to at least 7 days.

Original languageEnglish
Title of host publicationNEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference
DOIs
Publication statusPublished - 2009 Sep 21
EventIEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009 - Boston, MA, United States
Duration: 2009 Apr 32009 Apr 5

Publication series

NameBioengineering, Proceedings of the Northeast Conference
ISSN (Print)1071-121X

Other

OtherIEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009
CountryUnited States
CityBoston, MA
Period09-04-0309-04-05

Fingerprint

Hip prostheses
Antibiotics
Anti-Bacterial Agents
Cefuroxime
Vancomycin
Titanium
Titanium alloys
Copolymers
polylactic acid-polyglycolic acid copolymer

All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Chen, K. H., Lai, G. A., Chen, S. D., Shiu, J. C., & Yeh, M-L. (2009). Prolong antibiotics release by encapsulating PLGA for hip prosthesis. In NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference [4967627] (Bioengineering, Proceedings of the Northeast Conference). https://doi.org/10.1109/NEBC.2009.4967627
Chen, K. H. ; Lai, G. A. ; Chen, S. D. ; Shiu, J. C. ; Yeh, Ming-Long. / Prolong antibiotics release by encapsulating PLGA for hip prosthesis. NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference. 2009. (Bioengineering, Proceedings of the Northeast Conference).
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abstract = "In this study, encapsulating antibiotic loaded titanium alloy by polylactide-co-polyglycoJide copolymer (PLGA) for preventing burst releasing and extending antibiotic releasing time will be make for potential future hip prosthesis with deep infection prevention ability. Antibiotics, vancomycin and cefuroxime, were used to measure their temporal release from titanium disc. The result by elution test showed non PLGA coated of antibiotic loaded groups was released at the first hour. For PLGA (85/15) coated groups, vancomycin could still be detected after 5 days, and cefuroxime groups extended the releasing period to at least 7 days.",
author = "Chen, {K. H.} and Lai, {G. A.} and Chen, {S. D.} and Shiu, {J. C.} and Ming-Long Yeh",
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Chen, KH, Lai, GA, Chen, SD, Shiu, JC & Yeh, M-L 2009, Prolong antibiotics release by encapsulating PLGA for hip prosthesis. in NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference., 4967627, Bioengineering, Proceedings of the Northeast Conference, IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009, Boston, MA, United States, 09-04-03. https://doi.org/10.1109/NEBC.2009.4967627

Prolong antibiotics release by encapsulating PLGA for hip prosthesis. / Chen, K. H.; Lai, G. A.; Chen, S. D.; Shiu, J. C.; Yeh, Ming-Long.

NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference. 2009. 4967627 (Bioengineering, Proceedings of the Northeast Conference).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - In this study, encapsulating antibiotic loaded titanium alloy by polylactide-co-polyglycoJide copolymer (PLGA) for preventing burst releasing and extending antibiotic releasing time will be make for potential future hip prosthesis with deep infection prevention ability. Antibiotics, vancomycin and cefuroxime, were used to measure their temporal release from titanium disc. The result by elution test showed non PLGA coated of antibiotic loaded groups was released at the first hour. For PLGA (85/15) coated groups, vancomycin could still be detected after 5 days, and cefuroxime groups extended the releasing period to at least 7 days.

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Chen KH, Lai GA, Chen SD, Shiu JC, Yeh M-L. Prolong antibiotics release by encapsulating PLGA for hip prosthesis. In NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference. 2009. 4967627. (Bioengineering, Proceedings of the Northeast Conference). https://doi.org/10.1109/NEBC.2009.4967627