Prolongation of heart allograft survival of rats treated by a Th2 inhibitor

Li Wen Hsu, Shigeru Goto, Yu Chun Lin, Chia Yun Lai, Hui Peng Tseng, Chia Ling Wu, Roger Lord, Seigo Kitano, Shu Hui Chen, Chao Long Chen

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In terms of Th1/Th2 balance in response to signals given during donor antigen presentation, induction of tolerance is more often correlated with Th2-type than with Th1-type reactions. However, in our study, heart allograft survival was prolonged by treatment of rats with a Th2 inhibitor. Suplatast tosilate (IPD; Taiho; Tokyo, Japan) is a novel immunoregulator that suppresses IgE production and eosinophil infiltration through selective inhibition of interleukin (IL)-4 and IL-5 synthesis by Th2-like cells but not IFN-γ production in Th1 cells. Five LEW rats of DA heart grafts were treated with IPD (100 μg/day, p.o.) for 10 days. Heart allograft survival of all IPD-treated cases was prolonged more than 14 days while the beating of heart grafts in control groups was stopped within 9 days. In an in vitro study, the cell proliferation both in Con A blast and in mixed lymphocyte reaction assay was suppressed by IPD in dose-dependent manner. We could at least in part conclude that Th2 inhibition might temporarily suppress heart allograft rejection.

Original languageEnglish
Pages (from-to)385-388
Number of pages4
JournalTransplant Immunology
Volume11
Issue number3-4
DOIs
Publication statusPublished - 2003 Jul

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Transplantation

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