Prolonged morphine treatment relieves thermal hyperalgesia in rats with sciatic nerve constriction injury

K. S. Chu, H. P. Chen, F. C. Kang, Yu-Chuan Tsai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We examined the effects of chronic morphine treatment with regular intermittent administration in a modified chronic constriction injury (CCI) model of the rat sciatic nerve originally introduced by Bennett and Xie. A painful neuropathy was induced over the left hind limb with sciatic nerve ligation, and sham surgery was done on the opposite side in male Sprague- Dawley rats. Paw-withdrawal latency (PWL) was obtained one day before surgery (pre-op baseline) and on the fourth day after surgery (post-op) to assure the development of thermal hyperalgesia. Morphine hydrochloride (5, 10, 15, and 20 mg/kg per day) was subcutaneously administered for 7 days to four experimental groups. The control group received normal saline rather than morphine under the same injection protocol. PWLs were evaluated on days 5, 7, 9, and 11 of the treatment. PWL decreased to 50-60% of the pre-op baseline or sham limb on the fourth day after surgery. Morphine's ability to reverse PWL appeared dose-related, and no tolerance developed during treatment with chronic intermittent administration. This may indicate that prolonged use of intermittently-administered morphine can be a feasible regimen for relief of neuropathic pain.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
JournalKaohsiung Journal of Medical Sciences
Volume16
Issue number1
Publication statusPublished - 2000 Apr 2

Fingerprint

Hyperalgesia
Sciatic Nerve
Constriction
Morphine
Ambulatory Surgical Procedures
Wounds and Injuries
Extremities
Therapeutics
Neuralgia
Ligation
Sprague Dawley Rats
Control Groups
Injections

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chu, K. S. ; Chen, H. P. ; Kang, F. C. ; Tsai, Yu-Chuan. / Prolonged morphine treatment relieves thermal hyperalgesia in rats with sciatic nerve constriction injury. In: Kaohsiung Journal of Medical Sciences. 2000 ; Vol. 16, No. 1. pp. 20-25.
@article{da3a12190e9746ee99dbc773a198b7c8,
title = "Prolonged morphine treatment relieves thermal hyperalgesia in rats with sciatic nerve constriction injury",
abstract = "We examined the effects of chronic morphine treatment with regular intermittent administration in a modified chronic constriction injury (CCI) model of the rat sciatic nerve originally introduced by Bennett and Xie. A painful neuropathy was induced over the left hind limb with sciatic nerve ligation, and sham surgery was done on the opposite side in male Sprague- Dawley rats. Paw-withdrawal latency (PWL) was obtained one day before surgery (pre-op baseline) and on the fourth day after surgery (post-op) to assure the development of thermal hyperalgesia. Morphine hydrochloride (5, 10, 15, and 20 mg/kg per day) was subcutaneously administered for 7 days to four experimental groups. The control group received normal saline rather than morphine under the same injection protocol. PWLs were evaluated on days 5, 7, 9, and 11 of the treatment. PWL decreased to 50-60{\%} of the pre-op baseline or sham limb on the fourth day after surgery. Morphine's ability to reverse PWL appeared dose-related, and no tolerance developed during treatment with chronic intermittent administration. This may indicate that prolonged use of intermittently-administered morphine can be a feasible regimen for relief of neuropathic pain.",
author = "Chu, {K. S.} and Chen, {H. P.} and Kang, {F. C.} and Yu-Chuan Tsai",
year = "2000",
month = "4",
day = "2",
language = "English",
volume = "16",
pages = "20--25",
journal = "Kaohsiung Journal of Medical Sciences",
issn = "1607-551X",
publisher = "Elsevier (Singapore) Pte Ltd",
number = "1",

}

Prolonged morphine treatment relieves thermal hyperalgesia in rats with sciatic nerve constriction injury. / Chu, K. S.; Chen, H. P.; Kang, F. C.; Tsai, Yu-Chuan.

In: Kaohsiung Journal of Medical Sciences, Vol. 16, No. 1, 02.04.2000, p. 20-25.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prolonged morphine treatment relieves thermal hyperalgesia in rats with sciatic nerve constriction injury

AU - Chu, K. S.

AU - Chen, H. P.

AU - Kang, F. C.

AU - Tsai, Yu-Chuan

PY - 2000/4/2

Y1 - 2000/4/2

N2 - We examined the effects of chronic morphine treatment with regular intermittent administration in a modified chronic constriction injury (CCI) model of the rat sciatic nerve originally introduced by Bennett and Xie. A painful neuropathy was induced over the left hind limb with sciatic nerve ligation, and sham surgery was done on the opposite side in male Sprague- Dawley rats. Paw-withdrawal latency (PWL) was obtained one day before surgery (pre-op baseline) and on the fourth day after surgery (post-op) to assure the development of thermal hyperalgesia. Morphine hydrochloride (5, 10, 15, and 20 mg/kg per day) was subcutaneously administered for 7 days to four experimental groups. The control group received normal saline rather than morphine under the same injection protocol. PWLs were evaluated on days 5, 7, 9, and 11 of the treatment. PWL decreased to 50-60% of the pre-op baseline or sham limb on the fourth day after surgery. Morphine's ability to reverse PWL appeared dose-related, and no tolerance developed during treatment with chronic intermittent administration. This may indicate that prolonged use of intermittently-administered morphine can be a feasible regimen for relief of neuropathic pain.

AB - We examined the effects of chronic morphine treatment with regular intermittent administration in a modified chronic constriction injury (CCI) model of the rat sciatic nerve originally introduced by Bennett and Xie. A painful neuropathy was induced over the left hind limb with sciatic nerve ligation, and sham surgery was done on the opposite side in male Sprague- Dawley rats. Paw-withdrawal latency (PWL) was obtained one day before surgery (pre-op baseline) and on the fourth day after surgery (post-op) to assure the development of thermal hyperalgesia. Morphine hydrochloride (5, 10, 15, and 20 mg/kg per day) was subcutaneously administered for 7 days to four experimental groups. The control group received normal saline rather than morphine under the same injection protocol. PWLs were evaluated on days 5, 7, 9, and 11 of the treatment. PWL decreased to 50-60% of the pre-op baseline or sham limb on the fourth day after surgery. Morphine's ability to reverse PWL appeared dose-related, and no tolerance developed during treatment with chronic intermittent administration. This may indicate that prolonged use of intermittently-administered morphine can be a feasible regimen for relief of neuropathic pain.

UR - http://www.scopus.com/inward/record.url?scp=0034063026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034063026&partnerID=8YFLogxK

M3 - Article

C2 - 10741012

AN - SCOPUS:0034063026

VL - 16

SP - 20

EP - 25

JO - Kaohsiung Journal of Medical Sciences

JF - Kaohsiung Journal of Medical Sciences

SN - 1607-551X

IS - 1

ER -