Propranolol disposition in Chinese subjects of different CYP2D6 genotypes

Ming Liang Lai, Su Lan Wang, Ming-Derg Lai, Emil T. Lin, Mary Tse, Jin ding Huang

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Propranolol pharmacokinetics among different genotypes of CYP2D6 was compared in this study. The Chinese (Han) population consisted of 44 healthy unrelated individuals living in southern Taiwan. Endonuclease tests based on polymerase chain reaction were used to determine C T 188 genotypes of CYP2D6 in leukocyte deoxyribonucleic acid. Based on codon 188 genotypes, subjects were categorized into three groups: homozygous C C 188 (n = 13), heterozygous C T 188 (n = 14); and homozygous T T 188 (n = 17). Each subject was given a 40 mg propranolol tablet. Blood samples were drawn before and 12 hours after propranolol administration to measure propranolol and 4-hydroxypropranolol. Three genotypes showed distinct time profiles of plasma propranolol and 4-hydroxypropranolol. The area under plasma concentration curve values (mean ± SEM), were 322.0 ± 40.8, 481.6 ± 77.5, and 766.1 ± 92.8 nmol · hr/L, respectively, for C C 188 , C T 188 , and T T 188 subjects (p < 0.05). The 48-hour excreted amount of 4-hydroxy-S-propranolol-O-glucuronide, but not 4-hydroxy-R-propranolol-O-glucuronide, was significantly higher for C C 188 than for T T 188 subjects (p < 0.05). This study shows a different propranolol disposition in Chinese subjects of different CYP2D6 genotypes.

Original languageEnglish
Pages (from-to)264-268
Number of pages5
JournalClinical Pharmacology and Therapeutics
Volume58
Issue number3
DOIs
Publication statusPublished - 1995 Jan 1

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Cytochrome P-450 CYP2D6
Propranolol
Genotype
Endonucleases
Taiwan
Codon
Tablets
Leukocytes
Pharmacokinetics
Polymerase Chain Reaction
DNA
Population

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Lai, Ming Liang ; Wang, Su Lan ; Lai, Ming-Derg ; Lin, Emil T. ; Tse, Mary ; Huang, Jin ding. / Propranolol disposition in Chinese subjects of different CYP2D6 genotypes. In: Clinical Pharmacology and Therapeutics. 1995 ; Vol. 58, No. 3. pp. 264-268.
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Propranolol disposition in Chinese subjects of different CYP2D6 genotypes. / Lai, Ming Liang; Wang, Su Lan; Lai, Ming-Derg; Lin, Emil T.; Tse, Mary; Huang, Jin ding.

In: Clinical Pharmacology and Therapeutics, Vol. 58, No. 3, 01.01.1995, p. 264-268.

Research output: Contribution to journalArticle

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AB - Propranolol pharmacokinetics among different genotypes of CYP2D6 was compared in this study. The Chinese (Han) population consisted of 44 healthy unrelated individuals living in southern Taiwan. Endonuclease tests based on polymerase chain reaction were used to determine C T 188 genotypes of CYP2D6 in leukocyte deoxyribonucleic acid. Based on codon 188 genotypes, subjects were categorized into three groups: homozygous C C 188 (n = 13), heterozygous C T 188 (n = 14); and homozygous T T 188 (n = 17). Each subject was given a 40 mg propranolol tablet. Blood samples were drawn before and 12 hours after propranolol administration to measure propranolol and 4-hydroxypropranolol. Three genotypes showed distinct time profiles of plasma propranolol and 4-hydroxypropranolol. The area under plasma concentration curve values (mean ± SEM), were 322.0 ± 40.8, 481.6 ± 77.5, and 766.1 ± 92.8 nmol · hr/L, respectively, for C C 188 , C T 188 , and T T 188 subjects (p < 0.05). The 48-hour excreted amount of 4-hydroxy-S-propranolol-O-glucuronide, but not 4-hydroxy-R-propranolol-O-glucuronide, was significantly higher for C C 188 than for T T 188 subjects (p < 0.05). This study shows a different propranolol disposition in Chinese subjects of different CYP2D6 genotypes.

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